Detailed information of TA system TA025320

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 1835518..1836044
• Replicon: chromosome
• Accession: NC_015581
• Organism: Thioalkalimicrobium cyclicum ALM1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: F6DB18
• Locus tag: THICY_RS08085
• Protein ID: WP_013836122.1
• Coordinates: 1835745..1836044 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: F6DB17
• Locus tag: THICY_RS08080
• Protein ID: WP_013836121.1
• Coordinates: 1835518..1835748 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THICY_RS08060	1830827..1831603	-	777	WP_173358413.1	tRNA 2-thiocytidine biosynthesis protein TtcA	-
THICY_RS08065	1831676..1832776	-	1101	WP_013836119.1	tRNA (uridine(54)-C5)-methyltransferase TrmA	-
THICY_RS08070	1832970..1834952	-	1983	Protein_1578	acyltransferase	-
THICY_RS08075	1835067..1835462	+	396	WP_013836120.1	transcriptional regulator	-
THICY_RS08080	1835518..1835748	+	231	WP_013836121.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
THICY_RS08085	1835745..1836044	+	300	WP_013836122.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
THICY_RS08090	1836501..1838378	+	1878	WP_013836123.1	phosphomethylpyrimidine synthase ThiC	-
THICY_RS08095	1838410..1839435	+	1026	WP_173358419.1	FAD-dependent oxidoreductase	-
THICY_RS08100	1839553..1839747	+	195	WP_013836125.1	sulfur carrier protein ThiS	-
THICY_RS08105	1839907..1840716	+	810	WP_013836126.1	thiazole synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Antitoxin ParD (6-74)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11655.16 Da
• Isoelectric Point: 7.4627

>T25320 WP_013836122.1 NC_015581:1835745-1836044 [Thiomicrospira cyclica ALM1]
MKIELSPKAQEDLSYIWDYTYHQWGTMQAETYVRNIWHAIESLKSSYNSSQSIDFVRAGYRKIQTGSHVIFFKQASDTIT
VIRILHQQMDISRHLSTDL

Nucleotide

• Length: 300 bp

>T25320 NC_015581:1835745-1836044 [Thiomicrospira cyclica ALM1]
ATGAAGATTGAACTATCACCCAAAGCGCAAGAAGATTTAAGTTATATTTGGGACTACACCTACCACCAATGGGGCACAAT
GCAAGCTGAAACCTACGTTCGCAACATTTGGCATGCTATTGAAAGTTTAAAATCCAGTTACAACTCTTCACAAAGTATCG
ATTTTGTTAGAGCGGGTTACCGCAAAATACAAACCGGTTCACATGTCATCTTTTTTAAACAAGCTTCAGACACTATCACC
GTCATTCGTATTCTTCATCAGCAAATGGATATTTCCAGACACCTCTCCACCGATTTGTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8610.77 Da
• Isoelectric Point: 4.7204

>AT25320 WP_013836121.1 NC_015581:1835518-1835748 [Thiomicrospira cyclica ALM1]
MATMNISLPDKMKDWVEESVQTGLYANASDYVRDLIRQDHQKMAALRQALIEGEKSGFACEFDIEAFINTKKQAAQ

Nucleotide

• Length: 231 bp

>AT25320 NC_015581:1835518-1835748 [Thiomicrospira cyclica ALM1]
ATGGCGACTATGAATATTTCGTTACCGGATAAAATGAAAGACTGGGTTGAAGAGTCGGTGCAAACAGGGCTTTATGCCAA
TGCATCGGATTATGTTCGTGACCTAATTCGTCAGGATCATCAAAAAATGGCGGCGTTACGCCAAGCGTTAATCGAAGGTG
AAAAGTCCGGTTTTGCATGTGAATTTGATATCGAGGCGTTTATCAACACTAAAAAACAAGCTGCGCAATGA

Structures

Toxin

• AlphaFold DB: F6DB18

Antitoxin

• AlphaFold DB: F6DB17