253199

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4648664..4650237 Replicon chromosome
Accession NZ_CP102108
Organism Aeromonas veronii strain GD21SC2322TT

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NQU90_RS21490 Protein ID WP_019841146.1
Coordinates 4648664..4649983 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NQU90_RS21495 Protein ID WP_017410478.1
Coordinates 4649983..4650237 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQU90_RS21475 (NQU90_21475) 4644575..4645339 + 765 WP_257124050.1 ATP-binding cassette domain-containing protein -
NQU90_RS21480 (NQU90_21480) 4645373..4646266 + 894 WP_257125030.1 ABC transporter substrate-binding protein -
NQU90_RS21485 (NQU90_21485) 4646263..4648245 + 1983 WP_257124051.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
NQU90_RS21490 (NQU90_21490) 4648664..4649983 - 1320 WP_019841146.1 type II toxin-antitoxin system HipA family toxin Toxin
NQU90_RS21495 (NQU90_21495) 4649983..4650237 - 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
NQU90_RS21500 (NQU90_21500) 4650407..4650835 - 429 WP_042013332.1 DUF86 domain-containing protein -
NQU90_RS21505 (NQU90_21505) 4650828..4651277 - 450 WP_160836704.1 nucleotidyltransferase domain-containing protein -
NQU90_RS21510 (NQU90_21510) 4651913..4652926 - 1014 WP_000845048.1 class 1 integron integrase IntI1 -
NQU90_RS21515 (NQU90_21515) 4653218..4653772 + 555 WP_063840321.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr5 -
NQU90_RS21520 (NQU90_21520) 4653869..4654321 + 453 WP_001749986.1 NAD(+)--rifampin ADP-ribosyltransferase Arr-3 -
NQU90_RS21525 (NQU90_21525) 4654544..4654891 + 348 WP_000679427.1 quaternary ammonium compound efflux SMR transporter QacE delta 1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island aac(6')-Ib-cr / sul1 / mph(A) / blaTEM-1B / floR / tet(A) / qacE - 4648664..4690495 41831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49585.54 Da        Isoelectric Point: 6.6626

>T253199 WP_019841146.1 NZ_CP102108:c4649983-4648664 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDETYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDDRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYENHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT253199 WP_017410478.1 NZ_CP102108:c4650237-4649983 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References