Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 611406..612055 Replicon chromosome
Accession NZ_CP102099
Organism Acinetobacter colistiniresistens strain C-214

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NQU59_RS02925 Protein ID WP_257064929.1
Coordinates 611406..611825 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID S3TIA3
Locus tag NQU59_RS02930 Protein ID WP_016653313.1
Coordinates 611825..612055 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQU59_RS02890 (NQU59_02890) 606426..606878 - 453 WP_032879537.1 hypothetical protein -
NQU59_RS02895 (NQU59_02895) 607444..608331 - 888 WP_257064925.1 DMT family transporter -
NQU59_RS02900 (NQU59_02900) 608475..609179 - 705 WP_144583637.1 DUF1003 domain-containing protein -
NQU59_RS02905 (NQU59_02905) 609296..609535 - 240 WP_257064927.1 hypothetical protein -
NQU59_RS02910 (NQU59_02910) 609684..610385 - 702 WP_257064928.1 hypothetical protein -
NQU59_RS02915 (NQU59_02915) 610429..611004 - 576 WP_257066129.1 DUF4126 domain-containing protein -
NQU59_RS02920 (NQU59_02920) 611132..611275 - 144 WP_004637424.1 zinc ribbon-containing protein -
NQU59_RS02925 (NQU59_02925) 611406..611825 - 420 WP_257064929.1 type II toxin-antitoxin system VapC family toxin Toxin
NQU59_RS02930 (NQU59_02930) 611825..612055 - 231 WP_016653313.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NQU59_RS02935 (NQU59_02935) 612267..614873 - 2607 WP_257064934.1 Fe/S-dependent 2-methylisocitrate dehydratase AcnD -
NQU59_RS02940 (NQU59_02940) 614873..616030 - 1158 WP_005240547.1 2-methylcitrate synthase -
NQU59_RS02945 (NQU59_02945) 616149..617033 - 885 WP_257064935.1 methylisocitrate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15988.15 Da        Isoelectric Point: 6.3314

>T253195 WP_257064929.1 NZ_CP102099:c611825-611406 [Acinetobacter colistiniresistens]
MQAQYLLDTNICIYISKHQPESVRQHFEKHLPNRNILISVITLGELRFGAEKSQSKEKALKVIDEFTSMIQVAELDEDVA
DHYAQIRQALSSRSQIIGSNDLWLAAHARANNWVMVTNNEKEFLRVDGLRVENWVSNPL

Download         Length: 420 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9004.18 Da        Isoelectric Point: 4.5447

>AT253195 WP_016653313.1 NZ_CP102099:c612055-611825 [Acinetobacter colistiniresistens]
MSTAKVFMTGRSQAIRLPKEFRFEGTEVEIFRRGDEVILREKPITAEHLFNVLAQMPDDFYAEERVDQPPQEREEF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S3TIA3

References