Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1085433..1086199 Replicon chromosome
Accession NZ_CP102097
Organism Vibrio japonicus strain JCM 31412

Toxin (Protein)


Gene name - Uniprot ID A0A3Q0L5V0
Locus tag NP165_RS18275 Protein ID WP_011080392.1
Coordinates 1085433..1085930 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag NP165_RS18280 Protein ID WP_257085896.1
Coordinates 1085927..1086199 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP165_RS18245 (NP165_18245) 1080580..1080972 + 393 WP_257085886.1 hypothetical protein -
NP165_RS18250 (NP165_18250) 1081115..1081399 - 285 WP_257085885.1 hypothetical protein -
NP165_RS18255 (NP165_18255) 1082068..1082382 - 315 WP_140139434.1 DNA-binding transcriptional regulator -
NP165_RS18260 (NP165_18260) 1082369..1082701 - 333 WP_140139435.1 type II toxin-antitoxin system RelE/ParE family toxin -
NP165_RS18265 (NP165_18265) 1083497..1083709 - 213 WP_025553613.1 hypothetical protein -
NP165_RS18270 (NP165_18270) 1083971..1084924 + 954 WP_257085860.1 IS1595 family transposase -
NP165_RS18275 (NP165_18275) 1085433..1085930 - 498 WP_011080392.1 GNAT family N-acetyltransferase Toxin
NP165_RS18280 (NP165_18280) 1085927..1086199 - 273 WP_257085896.1 DUF1778 domain-containing protein Antitoxin
NP165_RS18285 (NP165_18285) 1086373..1087332 + 960 WP_257085897.1 IS1595 family transposase -
NP165_RS18290 (NP165_18290) 1087350..1087610 + 261 WP_257085898.1 hypothetical protein -
NP165_RS18295 (NP165_18295) 1087755..1088282 + 528 WP_257085899.1 endonuclease domain-containing protein -
NP165_RS18300 (NP165_18300) 1088279..1088389 + 111 WP_257086858.1 DUF3265 domain-containing protein -
NP165_RS18305 (NP165_18305) 1088420..1088767 + 348 WP_257085900.1 hypothetical protein -
NP165_RS18310 (NP165_18310) 1088742..1089695 - 954 WP_257085901.1 IS1595 family transposase -
NP165_RS18315 (NP165_18315) 1089754..1090404 + 651 Protein_1007 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1079284..1084924 5640
- inside Integron - - 1085285..1088282 2997
- inside IScluster/Tn - - 1078109..1091425 13316


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18486.13 Da        Isoelectric Point: 8.0487

>T253194 WP_011080392.1 NZ_CP102097:c1085930-1085433 [Vibrio japonicus]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFEDAENKLFITIADV
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9766.24 Da        Isoelectric Point: 6.3133

>AT253194 WP_257085896.1 NZ_CP102097:c1086199-1085927 [Vibrio japonicus]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADTMLLMEALDRPATENSKLKA
AADRYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5V0

Antitoxin

Source ID Structure

References