Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1072749..1073277 Replicon chromosome
Accession NZ_CP102097
Organism Vibrio japonicus strain JCM 31412

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag NP165_RS18185 Protein ID WP_005377002.1
Coordinates 1072749..1073039 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A377J6M1
Locus tag NP165_RS18190 Protein ID WP_040528287.1
Coordinates 1073029..1073277 (-) Length 83 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP165_RS18155 (NP165_18155) 1068226..1068579 + 354 WP_257085893.1 hypothetical protein -
NP165_RS18160 (NP165_18160) 1068740..1069075 + 336 WP_023585733.1 hypothetical protein -
NP165_RS18165 (NP165_18165) 1069249..1069683 + 435 WP_257085894.1 GNAT family N-acetyltransferase -
NP165_RS18170 (NP165_18170) 1069952..1070905 + 954 WP_257085860.1 IS1595 family transposase -
NP165_RS18175 (NP165_18175) 1070910..1071227 + 318 Protein_979 GNAT family N-acetyltransferase -
NP165_RS18180 (NP165_18180) 1071364..1072137 + 774 WP_257085895.1 aminoglycoside phosphotransferase family protein -
NP165_RS18185 (NP165_18185) 1072749..1073039 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP165_RS18190 (NP165_18190) 1073029..1073277 - 249 WP_040528287.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NP165_RS18195 (NP165_18195) 1073334..1073420 + 87 WP_257086857.1 DUF3265 domain-containing protein -
NP165_RS18200 (NP165_18200) 1074027..1074449 + 423 WP_193297996.1 GNAT family N-acetyltransferase -
NP165_RS18205 (NP165_18205) 1074594..1075040 + 447 WP_053316779.1 GNAT family N-acetyltransferase -
NP165_RS18210 (NP165_18210) 1075251..1075502 + 252 WP_017038856.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
NP165_RS18215 (NP165_18215) 1075492..1075779 + 288 WP_257085870.1 type II toxin-antitoxin system RelE/ParE family toxin -
NP165_RS18220 (NP165_18220) 1076081..1076302 + 222 WP_197942595.1 type II toxin-antitoxin system RelE/ParE family toxin -
NP165_RS18225 (NP165_18225) 1076299..1076583 + 285 WP_069502211.1 NadS family protein -
NP165_RS18230 (NP165_18230) 1077725..1077814 + 90 WP_074190930.1 DUF3265 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1069952..1070905 953
- inside IScluster/Tn - - 1078109..1091425 13316
- inside Integron - - 1009525..1078214 68689


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-83)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T253191 WP_005377002.1 NZ_CP102097:c1073039-1072749 [Vibrio japonicus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp


Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9021.33 Da        Isoelectric Point: 3.9610

>AT253191 WP_040528287.1 NZ_CP102097:c1073277-1073029 [Vibrio japonicus]
MTARILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDKLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A347UR03


Antitoxin

Source ID Structure
AlphaFold DB A0A377J6M1

References