Detailed information of TA system TA253187

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 856216..857659
• Replicon: chromosome
• Accession: NZ_CP102095
• Organism: Mycoplasmopsis agalactiae strain GM139

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: NQV05_RS03790
• Protein ID: WP_257056131.1
• Coordinates: 856823..857659 (+)
• Length: 279 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: NQV05_RS03785
• Protein ID: WP_257056130.1
• Coordinates: 856216..856830 (+)
• Length: 205 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NQV05_RS03760 (NQV05_03760)	851500..852381	-	882	WP_257056127.1	variable surface lipoprotein	-
NQV05_RS03765 (NQV05_03765)	852525..852797	-	273	Protein_717	hypothetical protein	-
NQV05_RS03770 (NQV05_03770)	852855..852926	-	72	Protein_718	variable surface lipoprotein	-
NQV05_RS03775 (NQV05_03775)	853725..854435	+	711	WP_257056128.1	variable surface lipoprotein	-
NQV05_RS03780 (NQV05_03780)	854527..856032	-	1506	WP_257056129.1	variable surface lipoprotein	-
NQV05_RS03785 (NQV05_03785)	856216..856830	+	615	WP_257056130.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
NQV05_RS03790 (NQV05_03790)	856823..857659	+	837	WP_257056131.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NQV05_RS03795 (NQV05_03795)	857784..858968	+	1185	WP_257056132.1	variable surface lipoprotein	-
NQV05_RS03800 (NQV05_03800)	859152..860102	+	951	WP_257056133.1	variable surface lipoprotein	-
NQV05_RS03805 (NQV05_03805)	860293..860922	+	630	WP_257056134.1	variable surface lipoprotein	-
NQV05_RS03810 (NQV05_03810)	860974..861696	-	723	WP_257056135.1	variable surface lipoprotein	-
NQV05_RS03815 (NQV05_03815)	862291..862404	-	114	Protein_727	variable surface lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-255)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (23-59)

Sequences

Toxin

Protein

• Length: 279 a.a.
• Molecular weight: 32558.55 Da
• Isoelectric Point: 6.5010

>T253187 WP_257056131.1 NZ_CP102095:856823-857659 [Mycoplasmopsis agalactiae]
MNKNKLISLCHKIADENSANFNVVLIQYFMEGVLRRISKSNERDNFVFKGGFLLSNIMGLDKRSTMDIDLEMIKVQKIST
AKIIEKFDNILKVDEEDGIKYQILKYTDIRKEHKYSGISISLLCQIENIRQIISIDIASGDVITPKEIVYEYKSMFSNQN
FSILAYNIETMLAEKLETIFSFGYFNTRFKDFYDVYVIYTFKSKNIDIDRLENACYNTFKNRNSEFNKQQLIELINKISL
NTLMNERNKYISQLNNQQEIDFKTVTDSIMKLLELIE

Nucleotide

• Length: 837 bp

Antitoxin

Protein

• Length: 205 a.a.
• Molecular weight: 24397.26 Da
• Isoelectric Point: 9.5715

>AT253187 WP_257056130.1 NZ_CP102095:856216-856830 [Mycoplasmopsis agalactiae]
MEQKQSNSKYYKIIYQLLYVNDGVITYKQLKEHNIPSIYLTRMIRKGTLIRKTKGIYIINNGHYDEYYFLSKNYNSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKYANVYYCDRDIHSIGLSEAKTIFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLIGAYIEYEKKDLKKLYEYAYKLGIHKKILEIFELFYE

Nucleotide

• Length: 615 bp