253184

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1537417..1538086 Replicon chromosome
Accession NZ_CP102094
Organism Streptococcus suis strain 12RC1

Toxin (Protein)


Gene name hicA Uniprot ID G7SGM1
Locus tag NQZ84_RS07505 Protein ID WP_014637653.1
Coordinates 1537904..1538086 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G7SGM2
Locus tag NQZ84_RS07500 Protein ID WP_014637654.1
Coordinates 1537417..1537866 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ84_RS07485 (NQZ84_07485) 1533112..1535004 - 1893 WP_044676989.1 C69 family dipeptidase -
NQZ84_RS07490 (NQZ84_07490) 1535197..1536057 - 861 WP_257048907.1 SAM-dependent methyltransferase TehB -
NQZ84_RS07495 (NQZ84_07495) 1536213..1537256 + 1044 WP_044680980.1 Zn-dependent alcohol dehydrogenase -
NQZ84_RS07500 (NQZ84_07500) 1537417..1537866 - 450 WP_014637654.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NQZ84_RS07505 (NQZ84_07505) 1537904..1538086 - 183 WP_014637653.1 type II toxin-antitoxin system HicA family toxin Toxin
NQZ84_RS07510 (NQZ84_07510) 1538980..1539837 - 858 WP_014637651.1 ABC transporter ATP-binding protein -
NQZ84_RS07515 (NQZ84_07515) 1539839..1540522 - 684 WP_172058408.1 hypothetical protein -
NQZ84_RS07520 (NQZ84_07520) 1540925..1541392 - 468 WP_014637647.1 SsrA-binding protein SmpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6653.87 Da        Isoelectric Point: 10.8207

>T253184 WP_014637653.1 NZ_CP102094:c1538086-1537904 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16664.69 Da        Isoelectric Point: 3.9458

>AT253184 WP_014637654.1 NZ_CP102094:c1537866-1537417 [Streptococcus suis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEYSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RNEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SGM1

Antitoxin

Source ID Structure
AlphaFold DB G7SGM2

References