253182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 963080..963581 Replicon chromosome
Accession NZ_CP102094
Organism Streptococcus suis strain 12RC1

Toxin (Protein)


Gene name relE Uniprot ID G7SDZ6
Locus tag NQZ84_RS04775 Protein ID WP_014637925.1
Coordinates 963315..963581 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G7SDZ5
Locus tag NQZ84_RS04770 Protein ID WP_014637924.1
Coordinates 963080..963331 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ84_RS04745 (NQZ84_04745) 958409..959575 + 1167 WP_044685228.1 ATP-grasp domain-containing protein -
NQZ84_RS04750 (NQZ84_04750) 959715..959855 + 141 WP_032536643.1 hypothetical protein -
NQZ84_RS04755 (NQZ84_04755) 959868..960257 + 390 WP_024395849.1 NisI/SpaI family lantibiotic immunity lipoprotein -
NQZ84_RS04760 (NQZ84_04760) 960266..961018 + 753 WP_014637922.1 ABC transporter ATP-binding protein -
NQZ84_RS04765 (NQZ84_04765) 961019..962989 + 1971 WP_257047305.1 FtsX-like permease family protein -
NQZ84_RS04770 (NQZ84_04770) 963080..963331 + 252 WP_014637924.1 DUF6290 family protein Antitoxin
NQZ84_RS04775 (NQZ84_04775) 963315..963581 + 267 WP_014637925.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ84_RS04780 (NQZ84_04780) 963620..964288 + 669 WP_024381849.1 response regulator transcription factor -
NQZ84_RS04785 (NQZ84_04785) 964285..965226 + 942 WP_014637927.1 sensor histidine kinase -
NQZ84_RS04790 (NQZ84_04790) 965303..966811 + 1509 WP_024401231.1 phosphoglucomutase -
NQZ84_RS04795 (NQZ84_04795) 966874..967944 - 1071 WP_044752114.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 858891..971731 112840


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10345.99 Da        Isoelectric Point: 10.7260

>T253182 WP_014637925.1 NZ_CP102094:963315-963581 [Streptococcus suis]
MKTSYKLVPTGRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9369.52 Da        Isoelectric Point: 3.6675

>AT253182 WP_014637924.1 NZ_CP102094:963080-963331 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAWAEYEADLANGIEPISWEEMLEDLGLTDE
DQL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SDZ6

Antitoxin

Source ID Structure
AlphaFold DB G7SDZ5

References