Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1880539..1881341 Replicon chromosome
Accession NZ_CP102089
Organism Staphylococcus capitis subsp. capitis strain H17

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag NF392_RS08995 Protein ID WP_023350564.1
Coordinates 1880880..1881341 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag NF392_RS08990 Protein ID WP_002469947.1
Coordinates 1880539..1880868 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF392_RS08930 1875770..1875991 - 222 WP_023350551.1 DUF2483 family protein -
NF392_RS08935 1875957..1876238 - 282 WP_023350552.1 hypothetical protein -
NF392_RS08940 1876260..1876478 - 219 WP_023350553.1 hypothetical protein -
NF392_RS08945 1876956..1877168 - 213 WP_002436465.1 DUF771 domain-containing protein -
NF392_RS08950 1877172..1877339 - 168 WP_023350555.1 hypothetical protein -
NF392_RS08955 1877441..1877635 - 195 WP_023350556.1 hypothetical protein -
NF392_RS08960 1877718..1877894 + 177 WP_023350557.1 hypothetical protein -
NF392_RS08965 1877920..1878018 - 99 Protein_1732 hypothetical protein -
NF392_RS08970 1878108..1878284 - 177 WP_023350559.1 hypothetical protein -
NF392_RS08975 1878367..1879137 - 771 WP_023350560.1 ParB N-terminal domain-containing protein -
NF392_RS08980 1879134..1880090 - 957 WP_049307539.1 ParB N-terminal domain-containing protein -
NF392_RS08985 1880106..1880345 - 240 WP_049399294.1 helix-turn-helix transcriptional regulator -
NF392_RS08990 1880539..1880868 + 330 WP_002469947.1 helix-turn-helix transcriptional regulator Antitoxin
NF392_RS08995 1880880..1881341 + 462 WP_023350564.1 ImmA/IrrE family metallo-endopeptidase Toxin
NF392_RS09000 1881360..1881884 + 525 WP_023350565.1 Ltp family lipoprotein -
NF392_RS09005 1881899..1882546 + 648 WP_023350566.1 hypothetical protein -
NF392_RS09010 1882606..1883667 + 1062 WP_023350567.1 tyrosine-type recombinase/integrase -
NF392_RS09025 1884179..1884754 - 576 Protein_1742 competence protein ComK -
NF392_RS09030 1884974..1885192 + 219 WP_023350569.1 IDEAL domain-containing protein -
NF392_RS09035 1885273..1886259 - 987 WP_023350570.1 lipoate--protein ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1837968..1883667 45699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(17-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18252.82 Da        Isoelectric Point: 5.8259

>T253180 WP_023350564.1 NZ_CP102089:1880880-1881341 [Staphylococcus capitis subsp. capitis]
MGLYEKMLIEHDYIEIRETDVMPNDLHGLWLGDLILIKRNLSETRKAEVLYEELAHHKLTYGNILDQSKDINRKFENYAR
RYGYEAALPLRIIVEAHNYGVNNLYELAEYVQLSEEHVLEILNHYKNKYGIGTHYGEYLITFDPLRVFKYKEI

Download         Length: 462 bp

>T253180 NZ_CP102089:1880880-1881341 [Staphylococcus capitis subsp. capitis]
ATGGGGTTATATGAAAAAATGTTAATAGAGCATGACTATATAGAAATCAGAGAAACAGATGTTATGCCTAATGACTTACA
CGGTTTATGGTTAGGCGATTTAATTCTAATTAAACGCAACCTTTCCGAAACACGCAAAGCCGAAGTGCTATACGAAGAAC
TAGCACATCACAAACTTACATATGGAAACATCTTAGATCAATCTAAAGATATAAACCGCAAATTTGAAAACTACGCTAGG
CGTTACGGATATGAAGCTGCTCTACCTTTACGCATTATTGTGGAGGCGCATAACTATGGTGTTAATAACTTATATGAACT
AGCTGAATATGTTCAATTAAGTGAAGAACACGTATTAGAAATATTGAATCATTACAAAAATAAATATGGTATTGGAACTC
ACTACGGAGAATACTTAATTACATTTGATCCGTTGAGGGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12713.28 Da        Isoelectric Point: 6.2406

>AT253180 WP_002469947.1 NZ_CP102089:1880539-1880868 [Staphylococcus capitis subsp. capitis]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRSEDFAKALSISTEYLLGFDKSEQQHEQPQH
RAAHLEGELTDDEWQRVLDYADFIRSKRK

Download         Length: 330 bp

>AT253180 NZ_CP102089:1880539-1880868 [Staphylococcus capitis subsp. capitis]
ATGAGAAATAATGATGAAATAATCACAATAATTAAATCAGCTATGAAAGAACAAGATATGTCACTTAGTGAATTGGCTCG
TCGTGTTGGAGTTGCTAAATCTGCTGTATCACGTTATTTAAATTTAACTAGAGAATTCCCATTAAATCGTTCAGAAGATT
TTGCAAAAGCACTTAGTATCAGTACAGAATATTTACTTGGTTTTGATAAAAGTGAACAACAACATGAACAACCACAACAT
CGTGCAGCTCATCTTGAAGGCGAATTAACTGATGACGAATGGCAACGAGTTTTAGATTATGCTGATTTTATAAGAAGTAA
ACGTAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References