Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1013081..1013887 Replicon chromosome
Accession NZ_CP102089
Organism Staphylococcus capitis subsp. capitis strain H17

Toxin (Protein)


Gene name tsbT Uniprot ID A0A507SPY8
Locus tag NF392_RS04870 Protein ID WP_023350045.1
Coordinates 1013708..1013887 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A1J4ECT8
Locus tag NF392_RS04865 Protein ID WP_002453580.1
Coordinates 1013081..1013680 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF392_RS04845 1008969..1010426 + 1458 WP_023350042.1 ABC transporter substrate-binding protein/permease -
NF392_RS04850 1010419..1011141 + 723 WP_030063521.1 amino acid ABC transporter ATP-binding protein -
NF392_RS04855 1011265..1012428 + 1164 WP_087671673.1 tRNA epoxyqueuosine(34) reductase QueG -
NF392_RS04860 1012431..1012901 + 471 WP_023350044.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NF392_RS04865 1013081..1013680 + 600 WP_002453580.1 glucosamine-6-phosphate isomerase Antitoxin
NF392_RS04870 1013708..1013887 + 180 WP_023350045.1 SAS053 family protein Toxin
NF392_RS04875 1014074..1014472 + 399 WP_023350046.1 hypothetical protein -
NF392_RS04880 1014626..1016011 + 1386 WP_023350047.1 class II fumarate hydratase -
NF392_RS04885 1016109..1016939 - 831 WP_049306969.1 RluA family pseudouridine synthase -
NF392_RS04890 1017115..1018227 + 1113 WP_030063524.1 GAF domain-containing sensor histidine kinase -
NF392_RS04895 1018247..1018870 + 624 WP_260832882.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 7012.37 Da        Isoelectric Point: 3.8420

>T253177 WP_023350045.1 NZ_CP102089:1013708-1013887 [Staphylococcus capitis subsp. capitis]
MNKEYESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDVHSDLNNE

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22720.63 Da        Isoelectric Point: 4.7928

>AT253177 WP_002453580.1 NZ_CP102089:1013081-1013680 [Staphylococcus capitis subsp. capitis]
MAMNFKVFENSERVAEYAADIIRKQFNNNPTTIAGFHLEKDHAPVLDELKKNVDTHAVDFSQINILDYDDNRSYYEALGV
PESQVYSISYEQDAIDFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKREVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARYV

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A507SPY8

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4ECT8

References