Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1490049..1490855 Replicon chromosome
Accession NZ_CP102087
Organism Staphylococcus capitis subsp. capitis strain K1-2-2-23

Toxin (Protein)


Gene name tsbT Uniprot ID A0A507SPY8
Locus tag NF398_RS07185 Protein ID WP_023350045.1
Coordinates 1490049..1490228 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A1J4ECT8
Locus tag NF398_RS07190 Protein ID WP_002453580.1
Coordinates 1490256..1490855 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF398_RS07160 1485066..1485689 - 624 WP_023350050.1 response regulator transcription factor -
NF398_RS07165 1485709..1486821 - 1113 WP_030063524.1 GAF domain-containing sensor histidine kinase -
NF398_RS07170 1486997..1487827 + 831 WP_049306969.1 RluA family pseudouridine synthase -
NF398_RS07175 1487925..1489310 - 1386 WP_023350047.1 class II fumarate hydratase -
NF398_RS07180 1489464..1489862 - 399 WP_023350046.1 hypothetical protein -
NF398_RS07185 1490049..1490228 - 180 WP_023350045.1 SAS053 family protein Toxin
NF398_RS07190 1490256..1490855 - 600 WP_002453580.1 glucosamine-6-phosphate isomerase Antitoxin
NF398_RS07195 1491035..1491505 - 471 WP_260833035.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NF398_RS07200 1491508..1492671 - 1164 WP_087671673.1 tRNA epoxyqueuosine(34) reductase QueG -
NF398_RS07205 1492795..1493517 - 723 WP_030063521.1 amino acid ABC transporter ATP-binding protein -
NF398_RS07210 1493510..1494967 - 1458 WP_023350042.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 7012.37 Da        Isoelectric Point: 3.8420

>T253170 WP_023350045.1 NZ_CP102087:c1490228-1490049 [Staphylococcus capitis subsp. capitis]
MNKEYESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDVHSDLNNE

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22720.63 Da        Isoelectric Point: 4.7928

>AT253170 WP_002453580.1 NZ_CP102087:c1490855-1490256 [Staphylococcus capitis subsp. capitis]
MAMNFKVFENSERVAEYAADIIRKQFNNNPTTIAGFHLEKDHAPVLDELKKNVDTHAVDFSQINILDYDDNRSYYEALGV
PESQVYSISYEQDAIDFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKREVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARYV

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A507SPY8

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4ECT8

References