Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 557157..558715 Replicon chromosome
Accession NC_015581
Organism Thioalkalimicrobium cyclicum ALM1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag THICY_RS02140 Protein ID WP_041435569.1
Coordinates 557405..558715 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag THICY_RS02135 Protein ID WP_013834974.1
Coordinates 557157..557399 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THICY_RS02110 552874..553569 - 696 WP_013834969.1 sulfite exporter TauE/SafE family protein -
THICY_RS02115 553574..554641 - 1068 WP_013834970.1 molybdenum ABC transporter ATP-binding protein -
THICY_RS02120 554651..555346 - 696 WP_041435284.1 molybdate ABC transporter permease subunit -
THICY_RS02125 555404..556150 - 747 WP_013834972.1 molybdate ABC transporter substrate-binding protein -
THICY_RS02130 556147..556947 - 801 WP_013834973.1 TOBE domain-containing protein -
THICY_RS02135 557157..557399 + 243 WP_013834974.1 helix-turn-helix domain-containing protein Antitoxin
THICY_RS02140 557405..558715 + 1311 WP_041435569.1 type II toxin-antitoxin system HipA family toxin Toxin
THICY_RS02145 558719..559825 - 1107 WP_013834976.1 ACR3 family arsenite efflux transporter -
THICY_RS02150 559896..561278 - 1383 WP_013834977.1 sigma-54 dependent transcriptional regulator -
THICY_RS02155 561275..562729 - 1455 WP_013834978.1 two-component sensor histidine kinase -
THICY_RS02160 562787..563704 - 918 WP_013834979.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(3-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 48333.74 Da        Isoelectric Point: 7.0020

>T25317 WP_041435569.1 NC_015581:557405-558715 [Thiomicrospira cyclica ALM1]
MNELVVSMNGLLVGQLIKHKSGALRFSYAKEWLASPYSRALSLSLPLSEKPYEGDLIYNFLDNLLPDNDLIRAKMQARFT
TSTTQPFDLLAAVGKDCVGAIQLTSHAPVEDSQASTGLEATVLNESQIADLLKNYAANPLGMQDLEQDFRISLAGAQEKT
ALLKMADKWYLPKGATPTTHILKLPIGVLAHNNLDLSQSCENEWLCMQIASAFGLPVAHTEVVQFDDQKAIAVERFDRKW
LPNERLVRLPQEDMCQVLGIAPALKYEADGGPSIRQIMDVLRGSQQAQKDREVFFKAQILFWLLAAPDGHGKNFSLFIEA
NNGYRLTPLYDILSAYPLMGGQGLQPQKIKMAMALQGKSRHYKWHSLSPRHFISTAKAVGYSEQLALSHLEEMCQKTAQV
IAQVKCQLPANFPEQIAQPIFEGILKKATIGINSPT

Download         Length: 1311 bp

>T25317 NC_015581:557405-558715 [Thiomicrospira cyclica ALM1]
ATGAATGAACTTGTGGTGTCGATGAATGGCTTGCTGGTCGGTCAGCTGATTAAACACAAAAGTGGTGCGTTGCGTTTTAG
TTACGCGAAAGAATGGCTGGCTTCGCCTTATTCGCGTGCTTTGTCCTTGTCTCTGCCGTTGTCAGAAAAACCTTATGAAG
GCGATCTAATTTACAATTTTTTAGATAACCTATTGCCTGACAATGATTTGATTCGTGCCAAAATGCAGGCGCGATTTACG
ACGTCCACAACCCAGCCATTTGATTTGTTGGCGGCGGTGGGTAAAGATTGCGTGGGTGCTATTCAATTGACCAGTCATGC
GCCTGTAGAGGATTCGCAAGCGAGTACAGGGCTTGAAGCGACAGTATTGAATGAATCCCAAATTGCCGATTTGTTAAAAA
ACTATGCCGCTAATCCGCTAGGCATGCAGGATTTGGAGCAGGATTTTCGTATTTCTCTTGCCGGTGCGCAAGAAAAAACA
GCCCTGCTCAAGATGGCGGATAAATGGTATTTGCCTAAAGGCGCAACCCCAACCACCCATATTTTAAAATTGCCGATCGG
TGTGTTGGCGCATAATAATCTTGATTTGTCGCAAAGTTGCGAAAACGAATGGTTGTGTATGCAAATTGCCTCTGCTTTCG
GATTGCCTGTCGCTCATACGGAGGTGGTGCAGTTTGACGATCAAAAGGCAATTGCGGTTGAGCGATTTGATCGAAAATGG
CTGCCTAACGAAAGGTTGGTGCGTTTGCCGCAAGAAGATATGTGCCAGGTGTTGGGTATCGCACCGGCACTCAAATATGA
GGCGGATGGTGGGCCAAGTATCAGACAAATTATGGATGTTCTGCGAGGCTCACAGCAGGCTCAAAAGGATCGAGAGGTCT
TTTTTAAAGCACAAATTCTGTTCTGGTTGCTAGCCGCACCCGATGGGCATGGTAAAAATTTCAGCCTGTTTATTGAAGCG
AATAACGGCTATCGTTTAACCCCACTGTATGACATTTTGTCAGCTTATCCTTTGATGGGCGGGCAAGGACTACAACCCCA
AAAAATAAAAATGGCGATGGCGTTACAGGGCAAATCCCGACATTATAAATGGCATAGCCTTAGCCCACGACATTTTATCA
GTACCGCGAAAGCCGTTGGTTACTCAGAGCAGCTTGCTCTAAGTCATCTTGAAGAGATGTGTCAAAAAACAGCGCAGGTG
ATTGCACAGGTTAAGTGCCAGTTGCCGGCAAATTTTCCTGAACAGATTGCGCAGCCTATTTTTGAAGGCATACTGAAAAA
AGCAACTATCGGTATTAACAGTCCAACCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9079.40 Da        Isoelectric Point: 5.7710

>AT25317 WP_013834974.1 NC_015581:557157-557399 [Thiomicrospira cyclica ALM1]
MRVNSIKELAVVLQNQRLSLDFSQSQLADLACTRQATVSNFENNPAQAKIETLFKLLSVLDLELEIRPKGQLAHDNKLDW

Download         Length: 243 bp

>AT25317 NC_015581:557157-557399 [Thiomicrospira cyclica ALM1]
ATGCGGGTAAACAGTATTAAAGAATTGGCGGTGGTGTTGCAGAATCAACGCTTGTCGCTGGATTTTTCGCAAAGTCAGTT
GGCGGATCTAGCGTGTACACGTCAAGCGACGGTGTCAAATTTTGAAAATAATCCGGCGCAAGCGAAGATTGAAACTTTAT
TTAAACTCTTGTCTGTGCTAGACCTTGAGTTGGAAATTCGCCCTAAAGGGCAGTTAGCGCATGATAACAAGCTGGATTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References