Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3890421..3891022 Replicon chromosome
Accession NZ_CP102086
Organism Proteus mirabilis strain MN029

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NOO60_RS17850 Protein ID WP_283533744.1
Coordinates 3890639..3891022 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag NOO60_RS17845 Protein ID WP_004246496.1
Coordinates 3890421..3890642 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOO60_RS17820 3886255..3886713 + 459 WP_004246490.1 dUTP diphosphatase -
NOO60_RS17825 3886833..3887438 + 606 WP_004246491.1 nucleoid occlusion factor SlmA -
NOO60_RS17830 3887757..3888401 - 645 WP_283533743.1 orotate phosphoribosyltransferase -
NOO60_RS17835 3888483..3889199 - 717 WP_004249760.1 ribonuclease PH -
NOO60_RS17840 3889326..3890189 + 864 WP_004249947.1 YicC/YloC family endoribonuclease -
NOO60_RS17845 3890421..3890642 + 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NOO60_RS17850 3890639..3891022 + 384 WP_283533744.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NOO60_RS17855 3891429..3891743 + 315 WP_041701465.1 helix-turn-helix transcriptional regulator -
NOO60_RS17860 3891756..3892994 + 1239 WP_020946511.1 HipA domain-containing protein -
NOO60_RS17865 3893351..3894250 - 900 WP_063108742.1 N-acetylmuramic acid 6-phosphate etherase -
NOO60_RS17870 3894359..3895096 + 738 WP_004249950.1 tetratricopeptide repeat protein -
NOO60_RS17875 3895192..3895650 - 459 WP_004249766.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14511.55 Da        Isoelectric Point: 8.5289

>T253165 WP_283533744.1 NZ_CP102086:3890639-3891022 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQHFLGVAGMSDPGRAEALIYRVQNRKHYEGITDVFERAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT253165 WP_004246496.1 NZ_CP102086:3890421-3890642 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References