Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3820242..3821840 Replicon chromosome
Accession NZ_CP102086
Organism Proteus mirabilis strain MN029

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NOO60_RS17495 Protein ID WP_063108770.1
Coordinates 3820497..3821840 (+) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NOO60_RS17490 Protein ID WP_041701484.1
Coordinates 3820242..3820493 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOO60_RS17465 3816140..3816670 + 531 WP_004246416.1 ATP-dependent protease subunit HslV -
NOO60_RS17470 3816683..3818023 + 1341 WP_004246417.1 HslU--HslV peptidase ATPase subunit -
NOO60_RS17475 3818122..3819039 + 918 WP_020946557.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
NOO60_RS17480 3819148..3819666 + 519 WP_004246419.1 ribonuclease E activity regulator RraA -
NOO60_RS17485 3819736..3820001 - 266 Protein_3386 IS4 family transposase -
NOO60_RS17490 3820242..3820493 + 252 WP_041701484.1 helix-turn-helix domain-containing protein Antitoxin
NOO60_RS17495 3820497..3821840 + 1344 WP_063108770.1 type II toxin-antitoxin system HipA family toxin Toxin
NOO60_RS17500 3822000..3822242 - 243 WP_012368679.1 cell division protein ZapB -
NOO60_RS17505 3822539..3823354 + 816 WP_004246421.1 MIP/aquaporin family protein -
NOO60_RS17510 3823397..3824929 + 1533 WP_004246422.1 glycerol kinase GlpK -
NOO60_RS17515 3825039..3826223 - 1185 WP_283533741.1 multidrug efflux MFS transporter EmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-399)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 49787.20 Da        Isoelectric Point: 5.3203

>T253164 WP_063108770.1 NZ_CP102086:3820497-3821840 [Proteus mirabilis]
MKAQILSVAMNGDLVGKLTKNTDGGMSFQYAEEWLAEPGARAISLSLPLQKGRIIGSAVYNFFSNLLPDSEAIIDRMQIR
FKVKTNHPFDLLAAVGRDCVGAIQLYSPDTEIPSVMETHAEPLNENQIEELLDGYQTAPLGMSEDVDFRISLAGAQEKTA
LLWYQDCWQRPQGSTPTSHIFKLPIGLIEHHNIDLRESCENEWLCLCIAREFGFPVTNAELAIFGQKKVLIVERFDRKWS
SSGNWLLRLPQEDCCQALSVAPALKYESDGGPGIESIMTLLLGSQKAIDDREMFFKSQILFWMLAAIDGHGKNFSIFIES
GTSFRLTPLYDVMSAFPIFEARGIEIKKAKMAMALQGKNRQYNFSMIQPRHFISTATKVGFPTKTAMELMVDMAEKTDAV
IATVSSQLPADFPEHISNAIFSGLSIQADKIKRWSSGTSSQNMMVSN

Download         Length: 1344 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9390.83 Da        Isoelectric Point: 9.8955

>AT253164 WP_041701484.1 NZ_CP102086:3820242-3820493 [Proteus mirabilis]
MKITTPSMLAAAIHDLRKQSKLTQAQTAEQVGLRQATVSEFENNPESTKLETLFKILASLELELHVVKRGKNLSEGKVWN
KEW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References