253163

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 735691..736712 Replicon chromosome
Accession NZ_CP102086
Organism Proteus mirabilis strain MN029

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag NOO60_RS03250 Protein ID WP_126656808.1
Coordinates 735691..736260 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag NOO60_RS03255 Protein ID WP_004245528.1
Coordinates 736260..736712 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOO60_RS03245 733221..735575 - 2355 WP_063108627.1 DNA polymerase II -
NOO60_RS03250 735691..736260 - 570 WP_126656808.1 PIN domain-containing protein Toxin
NOO60_RS03255 736260..736712 - 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
NOO60_RS03260 736840..737541 - 702 WP_004245527.1 thiamine ABC transporter ATP-binding protein ThiQ -
NOO60_RS03265 737534..739114 - 1581 WP_004245526.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
NOO60_RS03270 739114..740079 - 966 WP_221627503.1 thiamine ABC transporter substrate binding subunit -
NOO60_RS03275 740396..740926 + 531 WP_004245524.1 RNA pyrophosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21628.15 Da        Isoelectric Point: 7.3470

>T253163 WP_126656808.1 NZ_CP102086:c736260-735691 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLVAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT253163 WP_004245528.1 NZ_CP102086:c736712-736260 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References