Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 232343..233042 Replicon chromosome
Accession NZ_CP102086
Organism Proteus mirabilis strain MN029

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag NOO60_RS01090 Protein ID WP_004249093.1
Coordinates 232656..233042 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag NOO60_RS01085 Protein ID WP_004246828.1
Coordinates 232343..232663 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOO60_RS01055 227473..227748 - 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -
NOO60_RS01060 227803..228426 - 624 WP_004246821.1 guanylate kinase -
NOO60_RS01065 228728..229345 - 618 WP_004246822.1 trimeric intracellular cation channel family protein -
NOO60_RS01070 229482..230768 + 1287 WP_017827115.1 DUF3748 domain-containing protein -
NOO60_RS01075 230983..231867 + 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
NOO60_RS01080 231860..232294 + 435 WP_020946391.1 hypothetical protein -
NOO60_RS01085 232343..232663 - 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
NOO60_RS01090 232656..233042 - 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOO60_RS01095 233204..235276 - 2073 WP_041701373.1 glycine--tRNA ligase subunit beta -
NOO60_RS01100 235286..236191 - 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
NOO60_RS01105 236442..237023 + 582 WP_283533771.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T253162 WP_004249093.1 NZ_CP102086:c233042-232656 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT253162 WP_004246828.1 NZ_CP102086:c232663-232343 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References