Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 36216..37126 | Replicon | plasmid p5589-CTX-M-55 |
| Accession | NZ_CP102078 | ||
| Organism | Klebsiella pneumoniae strain 5589 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | NOV87_RS25890 | Protein ID | WP_004181896.1 |
| Coordinates | 36656..37126 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | NOV87_RS25885 | Protein ID | WP_004181895.1 |
| Coordinates | 36216..36659 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NOV87_RS25860 (NOV87_25860) | 31371..31586 | - | 216 | Protein_44 | IS200/IS605 family transposase | - |
| NOV87_RS25865 (NOV87_25865) | 31588..32157 | + | 570 | Protein_45 | transposase | - |
| NOV87_RS25870 (NOV87_25870) | 32849..34336 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| NOV87_RS25875 (NOV87_25875) | 34422..34844 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| NOV87_RS25880 (NOV87_25880) | 34844..36115 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| NOV87_RS25885 (NOV87_25885) | 36216..36659 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| NOV87_RS25890 (NOV87_25890) | 36656..37126 | + | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| NOV87_RS25895 (NOV87_25895) | 37236..37496 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| NOV87_RS25900 (NOV87_25900) | 38219..38377 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| NOV87_RS25905 (NOV87_25905) | 38980..39954 | + | 975 | WP_040222313.1 | hypothetical protein | - |
| NOV87_RS25910 (NOV87_25910) | 40152..40529 | - | 378 | WP_004181901.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / fosA3 / blaTEM-1B / blaCTX-M-55 / mph(E) / msr(E) | - | 1..290720 | 290720 | |
| - | flank | IS/Tn | - | - | 31771..32157 | 386 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T253156 WP_004181896.1 NZ_CP102078:36656-37126 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT253156 WP_004181895.1 NZ_CP102078:36216-36659 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |