Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4706256..4706772 Replicon chromosome
Accession NZ_CP102077
Organism Klebsiella pneumoniae strain 5589

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag NOV87_RS22885 Protein ID WP_009486548.1
Coordinates 4706256..4706540 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NOV87_RS22890 Protein ID WP_002886901.1
Coordinates 4706530..4706772 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV87_RS22860 (4701673) 4701673..4701936 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
NOV87_RS22865 (4702066) 4702066..4702239 + 174 WP_032433782.1 hypothetical protein -
NOV87_RS22870 (4702242) 4702242..4702985 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NOV87_RS22875 (4703342) 4703342..4705480 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NOV87_RS22880 (4705788) 4705788..4706252 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NOV87_RS22885 (4706256) 4706256..4706540 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOV87_RS22890 (4706530) 4706530..4706772 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NOV87_RS22895 (4706850) 4706850..4708760 - 1911 WP_009486549.1 PRD domain-containing protein -
NOV87_RS22900 (4708783) 4708783..4709937 - 1155 WP_002886900.1 lactonase family protein -
NOV87_RS22905 (4710004) 4710004..4710744 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T253153 WP_009486548.1 NZ_CP102077:c4706540-4706256 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT253153 WP_002886901.1 NZ_CP102077:c4706772-4706530 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References