Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2708990..2710578 Replicon chromosome
Accession NZ_CP102077
Organism Klebsiella pneumoniae strain 5589

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NOV87_RS13300 Protein ID WP_002904792.1
Coordinates 2708990..2710312 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NOV87_RS13305 Protein ID WP_002904790.1
Coordinates 2710312..2710578 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV87_RS13285 (2704046) 2704046..2706547 + 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -
NOV87_RS13290 (2706535) 2706535..2707539 + 1005 WP_032433097.1 fimbrial protein -
NOV87_RS13295 (2707681) 2707681..2708973 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NOV87_RS13300 (2708990) 2708990..2710312 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NOV87_RS13305 (2710312) 2710312..2710578 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NOV87_RS13310 (2710964) 2710964..2711290 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NOV87_RS13315 (2711287) 2711287..2711787 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NOV87_RS13320 (2711765) 2711765..2713144 - 1380 WP_256946380.1 nucleobase:cation symporter-2 family protein -
NOV87_RS13325 (2713490) 2713490..2714644 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NOV87_RS13330 (2714625) 2714625..2715548 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T253150 WP_002904792.1 NZ_CP102077:c2710312-2708990 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT253150 WP_002904790.1 NZ_CP102077:c2710578-2710312 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References