Detailed information of TA system TA025315

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 2372071..2372984
• Replicon: chromosome
• Accession: NC_015580
• Organism: Novosphingobium sp. PP1Y

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: F6INT6
• Locus tag: PP1Y_RS17295
• Protein ID: WP_013833373.1
• Coordinates: 2372457..2372984 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: -
• Locus tag: PP1Y_RS17290
• Protein ID: WP_198409095.1
• Coordinates: 2372071..2372460 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PP1Y_RS17265	2367213..2367500	+	288	WP_013833368.1	hypothetical protein	-
PP1Y_RS17270	2367508..2368430	+	923	Protein_2195	hypothetical protein	-
PP1Y_RS17275	2368531..2369007	+	477	WP_041559375.1	hypothetical protein	-
PP1Y_RS17280	2369036..2370178	+	1143	WP_083835217.1	phosphoadenosine phosphosulfate reductase family protein	-
PP1Y_RS17285	2370243..2371934	+	1692	WP_013833371.1	ATP-binding protein	-
PP1Y_RS17290	2372071..2372460	+	390	WP_198409095.1	hypothetical protein	Antitoxin
PP1Y_RS17295	2372457..2372984	+	528	WP_013833373.1	RES family NAD+ phosphorylase	Toxin
PP1Y_RS17300	2373410..2374789	+	1380	WP_013833374.1	DUF2384 domain-containing protein	-
PP1Y_RS17305	2374966..2375406	+	441	WP_148275114.1	hypothetical protein	-
PP1Y_RS17310	2375619..2376029	-	411	WP_013833376.1	type II toxin-antitoxin system PemK/MazF family toxin	-
PP1Y_RS17315	2376040..2376522	-	483	WP_013833377.1	helix-turn-helix domain-containing protein	-
PP1Y_RS17320	2376942..2377157	+	216	WP_041558951.1	hypothetical protein	-
PP1Y_RS17325	2377573..2377845	-	273	WP_041558952.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (12-168)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19202.68 Da
• Isoelectric Point: 5.5976

>T25315 WP_013833373.1 NC_015580:2372457-2372984 [Novosphingobium sp. PP1Y]
VKIATLGPDDVFYRYLTPKWAYVPLSGAGAAAEGGRFNRIGVEALYLARAPQTALEEYRQDSSLVPPAMLASYILSVDGV
VDLSGGYDPAHWADGWAEWDCSWRRMLRIDKVTPPSWILADQVISAGHKGILFPSIRHPGGTNLVIFNSNLTADDRLGVH
DPDGRLPKDQSSWPN

Nucleotide

• Length: 528 bp

>T25315 NC_015580:2372457-2372984 [Novosphingobium sp. PP1Y]
GTGAAGATCGCCACGCTTGGTCCCGATGACGTCTTCTACCGCTACCTCACCCCCAAATGGGCCTACGTGCCTTTGAGCGG
TGCGGGCGCGGCGGCCGAAGGCGGTCGTTTCAATCGCATCGGCGTCGAAGCGCTTTATCTCGCCCGAGCCCCGCAAACCG
CTTTGGAAGAGTACCGGCAGGATTCATCGCTCGTCCCGCCGGCGATGTTGGCGAGCTATATCCTTTCGGTCGACGGCGTC
GTTGATCTGTCGGGCGGCTATGACCCCGCTCATTGGGCGGACGGATGGGCGGAGTGGGACTGCTCCTGGCGGCGGATGCT
CCGGATCGACAAGGTGACGCCGCCCTCCTGGATATTGGCGGATCAGGTCATTTCCGCCGGCCACAAGGGCATTCTCTTTC
CCTCGATCCGGCATCCGGGTGGGACCAATCTCGTGATCTTCAATTCCAATCTGACAGCTGACGATCGGCTGGGGGTTCAC
GATCCCGACGGACGCCTGCCCAAGGATCAGTCTTCCTGGCCAAACTGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14033.86 Da
• Isoelectric Point: 7.4022

>AT25315 WP_198409095.1 NC_015580:2372071-2372460 [Novosphingobium sp. PP1Y]
MNAVSMERRTTAISGFVESLQEPRTPYISPKRFSAALGVQVAGLANLAGVHRNTLRNPASERLQDKLREMVRVISAAATL
TGDVSKAIFWYRNEPIADYDHKTAAELVAEGHSDAVMAHLRDLENGASG

Nucleotide

• Length: 390 bp

>AT25315 NC_015580:2372071-2372460 [Novosphingobium sp. PP1Y]
ATGAACGCTGTATCGATGGAGCGGCGCACCACTGCCATATCGGGGTTCGTCGAAAGCCTGCAAGAGCCGCGCACGCCCTA
TATCTCGCCCAAGCGGTTTTCCGCCGCATTGGGGGTACAGGTCGCGGGTCTCGCCAATCTGGCCGGAGTTCACCGCAATA
CCTTGCGCAACCCGGCTTCGGAACGTCTGCAGGACAAGCTTCGCGAGATGGTGAGGGTCATTTCCGCAGCCGCCACGCTG
ACCGGTGACGTGTCGAAGGCGATCTTCTGGTATCGCAACGAGCCGATCGCCGATTACGATCACAAGACCGCCGCCGAACT
TGTCGCTGAGGGCCATTCCGACGCGGTGATGGCGCATCTGCGCGATCTTGAGAACGGCGCCAGCGGGTGA

Structures

Toxin

• AlphaFold DB: F6INT6