Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1472317..1473053 Replicon chromosome
Accession NZ_CP102077
Organism Klebsiella pneumoniae strain 5589

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag NOV87_RS07275 Protein ID WP_032433360.1
Coordinates 1472571..1473053 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag NOV87_RS07270 Protein ID WP_003026799.1
Coordinates 1472317..1472583 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV87_RS07245 (1467963) 1467963..1469102 + 1140 WP_032433368.1 mannitol dehydrogenase -
NOV87_RS07250 (1469131) 1469131..1469793 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
NOV87_RS07255 (1469777) 1469777..1470781 + 1005 WP_032433364.1 dihydroxyacetone kinase subunit DhaK -
NOV87_RS07260 (1470799) 1470799..1471431 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
NOV87_RS07265 (1471441) 1471441..1472004 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
NOV87_RS07270 (1472317) 1472317..1472583 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
NOV87_RS07275 (1472571) 1472571..1473053 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
NOV87_RS07280 (1473414) 1473414..1474013 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
NOV87_RS07285 (1474226) 1474226..1475170 - 945 WP_077254249.1 fimbrial protein -
NOV87_RS07290 (1475182) 1475182..1475760 - 579 WP_032432061.1 type 1 fimbrial protein -
NOV87_RS07295 (1475764) 1475764..1476504 - 741 WP_050597964.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1440262..1483996 43734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T253145 WP_032433360.1 NZ_CP102077:1472571-1473053 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT253145 WP_003026799.1 NZ_CP102077:1472317-1472583 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References