Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1455626..1456269 Replicon chromosome
Accession NZ_CP102077
Organism Klebsiella pneumoniae strain 5589

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag NOV87_RS07180 Protein ID WP_032433387.1
Coordinates 1455853..1456269 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag NOV87_RS07175 Protein ID WP_001261276.1
Coordinates 1455626..1455856 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV87_RS07160 (1450648) 1450648..1451735 + 1088 Protein_1397 transcriptional regulator -
NOV87_RS07165 (1451738) 1451738..1453978 + 2241 WP_045326788.1 P-loop NTPase fold protein -
NOV87_RS07170 (1454506) 1454506..1455321 - 816 WP_032433388.1 hypothetical protein -
NOV87_RS07175 (1455626) 1455626..1455856 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NOV87_RS07180 (1455853) 1455853..1456269 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
NOV87_RS07185 (1456425) 1456425..1457405 + 981 WP_032433385.1 hypothetical protein -
NOV87_RS07190 (1457600) 1457600..1459171 - 1572 WP_256946424.1 AAA family ATPase -
NOV87_RS07195 (1459490) 1459490..1459738 + 249 WP_032433382.1 hypothetical protein -
NOV87_RS07200 (1459797) 1459797..1460315 + 519 WP_045326794.1 hypothetical protein -
NOV87_RS07205 (1460346) 1460346..1460837 + 492 WP_032433378.1 hypothetical protein -
NOV87_RS07210 (1460897) 1460897..1461100 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1440262..1483996 43734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T253144 WP_032433387.1 NZ_CP102077:1455853-1456269 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT253144 WP_001261276.1 NZ_CP102077:1455626-1455856 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References