Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 837532..838189 Replicon chromosome
Accession NZ_CP102077
Organism Klebsiella pneumoniae strain 5589

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NOV87_RS04195 Protein ID WP_002916310.1
Coordinates 837779..838189 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NOV87_RS04190 Protein ID WP_002916312.1
Coordinates 837532..837798 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV87_RS04165 (832688) 832688..834121 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
NOV87_RS04170 (834240) 834240..834968 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NOV87_RS04175 (835018) 835018..835329 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NOV87_RS04180 (835493) 835493..836152 + 660 WP_002916317.1 hemolysin III family protein -
NOV87_RS04185 (836303) 836303..837286 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NOV87_RS04190 (837532) 837532..837798 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NOV87_RS04195 (837779) 837779..838189 + 411 WP_002916310.1 protein YgfX Toxin
NOV87_RS04200 (838196) 838196..838717 - 522 WP_004144730.1 flavodoxin FldB -
NOV87_RS04205 (838818) 838818..839714 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NOV87_RS04210 (839737) 839737..840450 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NOV87_RS04215 (840456) 840456..842189 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T253143 WP_002916310.1 NZ_CP102077:837779-838189 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT253143 WP_002916312.1 NZ_CP102077:837532-837798 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References