Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 8537..9674 Replicon plasmid pJF3A-4253-3
Accession NZ_CP102072
Organism Enterococcus faecalis strain JF3A-4253

Toxin (Protein)


Gene name zeta Uniprot ID Q54944
Locus tag NP948_RS14565 Protein ID WP_001284311.1
Coordinates 8537..9400 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag NP948_RS14570 Protein ID WP_000301765.1
Coordinates 9402..9674 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP948_RS14540 3727..4104 - 378 WP_000361059.1 DUF6262 family protein -
NP948_RS14545 4111..6003 - 1893 WP_001557544.1 site-specific integrase -
NP948_RS14550 6000..7085 - 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
NP948_RS14555 7211..7798 + 588 WP_256969056.1 IS3 family transposase -
NP948_RS14560 7840..8274 + 435 Protein_9 rRNA adenine N-6-methyltransferase family protein -
NP948_RS14565 8537..9400 - 864 WP_001284311.1 zeta toxin family protein Toxin
NP948_RS14570 9402..9674 - 273 WP_000301765.1 antitoxin Antitoxin
NP948_RS14575 9691..9906 - 216 WP_001835296.1 peptide-binding protein -
NP948_RS14580 9998..10894 - 897 WP_001835294.1 ParA family protein -
NP948_RS14585 10983..12815 - 1833 WP_256969062.1 type IA DNA topoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(A) / ant(9)-Ia / optrA - 1..54298 54298


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32404.02 Da        Isoelectric Point: 6.9964

>T253139 WP_001284311.1 NZ_CP102072:c9400-8537 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLEKELNRKVSGKEIQ
PTLERIEQKMVLNKHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGI

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT253139 WP_000301765.1 NZ_CP102072:c9674-9402 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1GVN
PDB 3Q8X

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References