253138

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 22753..23861 Replicon plasmid pJF3A-4253-2
Accession NZ_CP102071
Organism Enterococcus faecalis strain JF3A-4253

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag NP948_RS14295 Protein ID WP_000233000.1
Coordinates 22753..23622 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag NP948_RS14300 Protein ID WP_000205227.1
Coordinates 23637..23861 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP948_RS14260 17952..18323 - 372 Protein_23 transposase -
NP948_RS14265 18551..19078 - 528 WP_002294507.1 phosphoribosyltransferase family protein -
NP948_RS14270 19122..19874 - 753 Protein_25 aminoglycoside 6-adenylyltransferase -
NP948_RS14275 20044..21483 - 1440 WP_001028144.1 aminoglycoside O-phosphotransferase APH(2'')-Ia -
NP948_RS14280 21484..21876 - 393 WP_000393259.1 GNAT family N-acetyltransferase -
NP948_RS14285 21895..22005 - 111 Protein_28 aminoglycoside 6-adenylyltransferase -
NP948_RS14290 22038..22772 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
NP948_RS14295 22753..23622 - 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
NP948_RS14300 23637..23861 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
NP948_RS14305 24004..25566 - 1563 WP_000136908.1 recombinase family protein -
NP948_RS14310 25568..25984 - 417 WP_000323438.1 recombinase -
NP948_RS14315 25985..26473 - 489 WP_225582191.1 DNA recombinase -
NP948_RS14320 26793..27470 - 678 Protein_35 DNA topoisomerase -
NP948_RS14325 27470..28087 - 618 WP_002295591.1 recombinase family protein -
NP948_RS14330 28101..28271 - 171 WP_000713595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T253138 WP_000233000.1 NZ_CP102071:c23622-22753 [Enterococcus faecalis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT253138 WP_000205227.1 NZ_CP102071:c23861-23637 [Enterococcus faecalis]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References