Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2787410..2787981 Replicon chromosome
Accession NZ_CP102070
Organism Enterococcus faecalis strain JF3A-4253

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NP948_RS13680 Protein ID WP_002354774.1
Coordinates 2787410..2787751 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag NP948_RS13685 Protein ID WP_002354773.1
Coordinates 2787751..2787981 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP948_RS13675 (2783425) 2783425..2787039 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
NP948_RS13680 (2787410) 2787410..2787751 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NP948_RS13685 (2787751) 2787751..2787981 - 231 WP_002354773.1 hypothetical protein Antitoxin
NP948_RS13690 (2788388) 2788388..2788603 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
NP948_RS13695 (2788742) 2788742..2789734 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
NP948_RS13700 (2789998) 2789998..2790636 - 639 WP_002375448.1 lytic polysaccharide monooxygenase -
NP948_RS13705 (2791322) 2791322..2792938 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T253131 WP_002354774.1 NZ_CP102070:c2787751-2787410 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT253131 WP_002354773.1 NZ_CP102070:c2787981-2787751 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References