Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 167142..167692 Replicon plasmid Lpl
Accession NC_015579
Organism Novosphingobium sp. PP1Y

Toxin (Protein)


Gene name parE Uniprot ID G6EGT7
Locus tag PP1Y_RS25095 Protein ID WP_007014466.1
Coordinates 167142..167444 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID F6ICG1
Locus tag PP1Y_RS01025 Protein ID WP_013831443.1
Coordinates 167447..167692 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PP1Y_RS01010 162449..163303 - 855 WP_041558059.1 hypothetical protein -
PP1Y_RS01015 163303..164946 - 1644 WP_013831441.1 ATP-binding protein -
PP1Y_RS01020 165522..166766 - 1245 WP_013831442.1 hypothetical protein -
PP1Y_RS25095 167142..167444 - 303 WP_007014466.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PP1Y_RS01025 167447..167692 - 246 WP_013831443.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
PP1Y_RS01030 167865..168497 + 633 WP_013831444.1 tyrosine-type recombinase/integrase -
PP1Y_RS01035 168711..169595 - 885 WP_013831446.1 LysR family transcriptional regulator -
PP1Y_RS01040 169710..171266 + 1557 WP_013831447.1 sulfatase-like hydrolase/transferase -
PP1Y_RS01045 171659..172072 - 414 WP_041558067.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..192103 192103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Antitoxin ParD

(1-74)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11270.64 Da        Isoelectric Point: 5.4710

>T25313 WP_007014466.1 NC_015579:c167444-167142 [Novosphingobium sp. PP1Y]
VPRFHLTRAAADDLTAIFLEGIEQFGLPQADAYHEGLSAIFAFLADYPHAARLREEISPPVRVHPYKAHLVIYDVGNEGE
VIILRVRHGREDWTSSNYDG

Download         Length: 303 bp

>T25313 NC_015579:c167444-167142 [Novosphingobium sp. PP1Y]
GTGCCACGTTTTCACTTAACACGCGCCGCAGCCGACGATCTGACAGCCATTTTTCTGGAAGGCATCGAGCAGTTTGGCTT
GCCGCAGGCTGACGCTTATCACGAAGGGCTGAGTGCGATTTTCGCGTTTCTCGCAGACTATCCCCATGCTGCGCGCTTGC
GAGAGGAAATCTCGCCGCCAGTTCGCGTGCATCCCTACAAGGCCCACCTGGTGATTTATGATGTAGGAAATGAGGGCGAG
GTCATCATTCTACGCGTCCGGCATGGTCGGGAAGATTGGACATCATCGAATTACGACGGTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8969.05 Da        Isoelectric Point: 4.7107

>AT25313 WP_013831443.1 NC_015579:c167692-167447 [Novosphingobium sp. PP1Y]
MATMNISLPDPMKQWVEAQADTGRYSNASDYVRDLIRRDQERADKIAAMQRLVDDARAGGLSDETMADIRARAISQAGLQ
A

Download         Length: 246 bp

>AT25313 NC_015579:c167692-167447 [Novosphingobium sp. PP1Y]
ATGGCTACGATGAACATCTCACTGCCCGATCCGATGAAGCAATGGGTGGAAGCGCAAGCTGATACTGGTCGGTATAGCAA
TGCCAGCGACTATGTGCGCGATCTTATCCGCCGTGACCAGGAACGCGCCGACAAGATTGCCGCCATGCAGCGCCTTGTCG
ACGACGCCCGAGCTGGCGGTCTGAGCGATGAGACGATGGCGGATATCCGGGCGCGAGCGATCAGCCAGGCAGGCCTGCAA
GCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G6EGT7

Antitoxin

Source ID Structure
AlphaFold DB A0A158S7A8

References