253124

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2480636..2481678 Replicon chromosome
Accession NZ_CP102070
Organism Enterococcus faecalis strain JF3A-4253

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag NP948_RS12260 Protein ID WP_010777936.1
Coordinates 2481019..2481678 (+) Length 220 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag NP948_RS12255 Protein ID WP_002402312.1
Coordinates 2480636..2481022 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP948_RS12210 (2476989) 2476989..2477369 - 381 WP_002402315.1 DUF86 domain-containing protein -
NP948_RS12215 (2477359) 2477359..2477685 - 327 WP_002394268.1 nucleotidyltransferase domain-containing protein -
NP948_RS12220 (2477745) 2477745..2478038 - 294 WP_002394269.1 hypothetical protein -
NP948_RS12225 (2478080) 2478080..2478232 - 153 WP_002380874.1 hypothetical protein -
NP948_RS12230 (2478459) 2478459..2478647 + 189 WP_002371434.1 hypothetical protein -
NP948_RS12235 (2478634) 2478634..2478795 - 162 WP_002380875.1 hypothetical protein -
NP948_RS12240 (2478818) 2478818..2479234 - 417 WP_002380876.1 DUF961 family protein -
NP948_RS12245 (2479234) 2479234..2479560 - 327 WP_002365226.1 hypothetical protein -
NP948_RS12250 (2479646) 2479646..2479897 - 252 WP_142429243.1 hypothetical protein -
NP948_RS12255 (2480636) 2480636..2481022 + 387 WP_002402312.1 helix-turn-helix transcriptional regulator Antitoxin
NP948_RS12260 (2481019) 2481019..2481678 + 660 WP_010777936.1 ImmA/IrrE family metallo-endopeptidase Toxin
NP948_RS12265 (2481694) 2481694..2482029 + 336 WP_002402309.1 helix-turn-helix domain-containing protein -
NP948_RS12270 (2482067) 2482067..2483398 - 1332 WP_002402308.1 FAD-dependent oxidoreductase -
NP948_RS12275 (2483497) 2483497..2484372 - 876 WP_010785430.1 aldo/keto reductase -
NP948_RS12280 (2484449) 2484449..2484868 - 420 WP_002380882.1 MerR family transcriptional regulator -
NP948_RS12285 (2484885) 2484885..2485465 - 581 Protein_2386 phosphoglycerate mutase family protein -
NP948_RS12290 (2485687) 2485687..2486015 + 329 Protein_2387 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2458415..2509316 50901


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(80-181)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 220 a.a.        Molecular weight: 26248.20 Da        Isoelectric Point: 6.4970

>T253124 WP_010777936.1 NZ_CP102070:2481019-2481678 [Enterococcus faecalis]
MIGLLLVDFISKELYFEAFNFSNELIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDE
VIITTNKELMLERKNFTKMHEVIHYYIDIPKINNATHTFSDILLKNGYLMEDFPKEYRANVGASMLMANDQALFYALKKF
YSFEEIAQYFFMSKSALRNRLIEHLMYVNNCTFAHANTLFNNYYFHKKTDIYRFIFNDS

Download         Length: 660 bp

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 15181.05 Da        Isoelectric Point: 4.7886

>AT253124 WP_002402312.1 NZ_CP102070:2480636-2481022 [Enterococcus faecalis]
VTIIKTNERLKQLRENKELTQKELADLLHMDRSVYNKIESGARPIRDNELIQFADFYNVSTDYLTNRTNNPIPPEEKTNV
GQNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKERNKKD

Download         Length: 387 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References