Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 17756..18893 Replicon plasmid pJF3A-223-4
Accession NZ_CP102068
Organism Enterococcus faecalis strain JF3A-223

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag NP947_RS14475 Protein ID WP_256969069.1
Coordinates 18030..18893 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag NP947_RS14470 Protein ID WP_000301765.1
Coordinates 17756..18028 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP947_RS14455 14615..16447 + 1833 WP_256969963.1 type IA DNA topoisomerase -
NP947_RS14460 16536..17432 + 897 WP_002387620.1 ParA family protein -
NP947_RS14465 17524..17739 + 216 WP_001835296.1 peptide-binding protein -
NP947_RS14470 17756..18028 + 273 WP_000301765.1 antitoxin Antitoxin
NP947_RS14475 18030..18893 + 864 WP_256969069.1 zeta toxin family protein Toxin
NP947_RS14485 19890..21122 + 1233 WP_256969066.1 DNA adenine methylase -
NP947_RS14490 21122..22096 + 975 WP_256969065.1 Dam family site-specific DNA-(adenine-N6)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid fexA / poxtA / Cfr(D) - 1..26169 26169
- flank IS/Tn - - 18957..19418 461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32440.98 Da        Isoelectric Point: 6.6610

>T253119 WP_256969069.1 NZ_CP102068:18030-18893 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVIAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKLESLQPPTPPIPKIPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT253119 WP_000301765.1 NZ_CP102068:17756-18028 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References