Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2692321..2692892 Replicon chromosome
Accession NZ_CP102065
Organism Enterococcus faecalis strain JF3A-223

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NP947_RS13125 Protein ID WP_010710856.1
Coordinates 2692321..2692662 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag NP947_RS13130 Protein ID WP_002354773.1
Coordinates 2692662..2692892 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP947_RS13120 (2688336) 2688336..2691950 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
NP947_RS13125 (2692321) 2692321..2692662 - 342 WP_010710856.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NP947_RS13130 (2692662) 2692662..2692892 - 231 WP_002354773.1 hypothetical protein Antitoxin
NP947_RS13135 (2693223) 2693223..2693438 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
NP947_RS13140 (2693577) 2693577..2694569 + 993 WP_002394775.1 biotin--[acetyl-CoA-carboxylase] ligase -
NP947_RS13145 (2694736) 2694736..2695374 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
NP947_RS13150 (2696059) 2696059..2697675 + 1617 WP_010710855.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13177.47 Da        Isoelectric Point: 9.3988

>T253111 WP_010710856.1 NZ_CP102065:c2692662-2692321 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPIISTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT253111 WP_002354773.1 NZ_CP102065:c2692892-2692662 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References