Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1404058..1405195 Replicon chromosome
Accession NZ_CP102065
Organism Enterococcus faecalis strain JF3A-223

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag NP947_RS06900 Protein ID WP_002401483.1
Coordinates 1404058..1404921 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag NP947_RS06905 Protein ID WP_000301765.1
Coordinates 1404923..1405195 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP947_RS06870 (1399857) 1399857..1400624 - 768 WP_002357481.1 ribonuclease HII -
NP947_RS06875 (1400626) 1400626..1401477 - 852 WP_002357480.1 ribosome biogenesis GTPase YlqF -
NP947_RS06880 (1401753) 1401753..1402184 - 432 Protein_1320 2-dehydropantoate 2-reductase -
NP947_RS06885 (1402240) 1402240..1402920 - 681 WP_010713944.1 IS6-like element IS1216 family transposase -
NP947_RS06890 (1402994) 1402994..1403281 - 288 Protein_1322 DnaJ domain-containing protein -
NP947_RS06895 (1403301) 1403301..1403618 - 318 WP_002300567.1 hypothetical protein -
NP947_RS06900 (1404058) 1404058..1404921 - 864 WP_002401483.1 zeta toxin family protein Toxin
NP947_RS06905 (1404923) 1404923..1405195 - 273 WP_000301765.1 antitoxin Antitoxin
NP947_RS06910 (1405212) 1405212..1405427 - 216 WP_001835296.1 peptide-binding protein -
NP947_RS06915 (1405519) 1405519..1406415 - 897 WP_002326827.1 ParA family protein -
NP947_RS06920 (1406518) 1406518..1406778 - 261 Protein_1328 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
NP947_RS06925 (1406948) 1406948..1407685 - 738 WP_002292226.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
NP947_RS06930 (1407810) 1407810..1407905 - 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
NP947_RS06935 (1407974) 1407974..1408096 - 123 Protein_1331 peptide-binding protein -
NP947_RS06940 (1408216) 1408216..1409742 - 1527 WP_025191980.1 type IA DNA topoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') - 1242579..1465855 223276
- inside IScluster/Tn erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') - 1402240..1434253 32013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T253105 WP_002401483.1 NZ_CP102065:c1404921-1404058 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT253105 WP_000301765.1 NZ_CP102065:c1405195-1404923 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References