Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4186825..4187443 Replicon chromosome
Accession NZ_CP102061
Organism Escherichia coli strain C31

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NP943_RS20335 Protein ID WP_001291435.1
Coordinates 4186825..4187043 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NP943_RS20340 Protein ID WP_000344800.1
Coordinates 4187069..4187443 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP943_RS20300 (4182112) 4182112..4182684 + 573 WP_000779831.1 YbaY family lipoprotein -
NP943_RS20305 (4182715) 4182715..4183026 - 312 WP_000409908.1 MGMT family protein -
NP943_RS20315 (4183405) 4183405..4183758 + 354 WP_000878135.1 DUF1428 family protein -
NP943_RS20320 (4183800) 4183800..4185350 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NP943_RS20325 (4185514) 4185514..4185984 - 471 WP_000136192.1 YlaC family protein -
NP943_RS20330 (4186100) 4186100..4186651 - 552 WP_000102539.1 maltose O-acetyltransferase -
NP943_RS20335 (4186825) 4186825..4187043 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NP943_RS20340 (4187069) 4187069..4187443 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NP943_RS20345 (4187989) 4187989..4191138 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
NP943_RS20350 (4191161) 4191161..4192354 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T253093 WP_001291435.1 NZ_CP102061:c4187043-4186825 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT253093 WP_000344800.1 NZ_CP102061:c4187443-4187069 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References