Detailed information of TA system TA253092

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4002446..4004135
• Replicon: chromosome
• Accession: NZ_CP102061
• Organism: Escherichia coli strain C31

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: NP943_RS19470
• Protein ID: WP_000365807.1
• Coordinates: 4003215..4004135 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: NP943_RS19465
• Protein ID: WP_256946698.1
• Coordinates: 4002446..4003228 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NP943_RS19460 (3999064)	3999064..4002162	-	3099	WP_000673070.1	type I restriction endonuclease	-
NP943_RS19465 (4002446)	4002446..4003228	+	783	WP_256946698.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
NP943_RS19470 (4003215)	4003215..4004135	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NP943_RS19475 (4004300)	4004300..4005076	-	777	WP_000171155.1	site-specific integrase	-
NP943_RS19480 (4005284)	4005284..4005619	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
NP943_RS19485 (4005846)	4005846..4006004	-	159	Protein_3801	integrase	-
NP943_RS19490 (4006053)	4006053..4006238	+	186	WP_000146240.1	hypothetical protein	-
NP943_RS19495 (4006453)	4006453..4007067	+	615	WP_001019923.1	YagU family protein	-
NP943_RS19500 (4007138)	4007138..4007304	+	167	Protein_3804	tail fiber assembly protein	-
NP943_RS19505 (4007316)	4007316..4007645	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
NP943_RS19510 (4007952)	4007952..4008662	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	3996196..4044352	48156

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T253092 WP_000365807.1 NZ_CP102061:4003215-4004135 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT253092 WP_256946698.1 NZ_CP102061:4002446-4003228 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWIRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0