Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3458614..3459209 Replicon chromosome
Accession NZ_CP102061
Organism Escherichia coli strain C31

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NP943_RS16805 Protein ID WP_000239579.1
Coordinates 3458859..3459209 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NP943_RS16800 Protein ID WP_001223208.1
Coordinates 3458614..3458865 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP943_RS16790 (3454279) 3454279..3458058 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
NP943_RS16795 (3458061) 3458061..3458402 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NP943_RS16800 (3458614) 3458614..3458865 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NP943_RS16805 (3458859) 3458859..3459209 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NP943_RS16810 (3459289) 3459289..3459819 - 531 WP_000055075.1 inorganic diphosphatase -
NP943_RS16815 (3460129) 3460129..3461085 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NP943_RS16820 (3461225) 3461225..3462727 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
NP943_RS16825 (3462741) 3462741..3463763 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T253088 WP_000239579.1 NZ_CP102061:3458859-3459209 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT253088 WP_001223208.1 NZ_CP102061:3458614-3458865 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References