Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2465826..2466626 Replicon chromosome
Accession NZ_CP102061
Organism Escherichia coli strain C31

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag NP943_RS12105 Protein ID WP_000342452.1
Coordinates 2465826..2466353 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag NP943_RS12110 Protein ID WP_001277107.1
Coordinates 2466360..2466626 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP943_RS12080 (2460902) 2460902..2461669 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
NP943_RS12085 (2461666) 2461666..2462943 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
NP943_RS12090 (2462940) 2462940..2463866 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NP943_RS12095 (2463914) 2463914..2465023 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NP943_RS12100 (2465446) 2465446..2465829 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
NP943_RS12105 (2465826) 2465826..2466353 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NP943_RS12110 (2466360) 2466360..2466626 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NP943_RS12115 (2466775) 2466775..2467878 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NP943_RS12120 (2468149) 2468149..2469003 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
NP943_RS12125 (2469248) 2469248..2470306 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
NP943_RS12130 (2470299) 2470299..2470967 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T253085 WP_000342452.1 NZ_CP102061:c2466353-2465826 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT253085 WP_001277107.1 NZ_CP102061:c2466626-2466360 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References