Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1789339..1789993 Replicon chromosome
Accession NZ_CP102061
Organism Escherichia coli strain C31

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag NP943_RS08680 Protein ID WP_000244765.1
Coordinates 1789339..1789746 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag NP943_RS08685 Protein ID WP_000354050.1
Coordinates 1789727..1789993 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP943_RS08660 (1785296) 1785296..1787029 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
NP943_RS08665 (1787035) 1787035..1787745 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NP943_RS08670 (1787770) 1787770..1788666 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NP943_RS08675 (1788778) 1788778..1789299 + 522 WP_001055874.1 flavodoxin FldB -
NP943_RS08680 (1789339) 1789339..1789746 - 408 WP_000244765.1 protein YgfX Toxin
NP943_RS08685 (1789727) 1789727..1789993 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
NP943_RS08690 (1790236) 1790236..1791216 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
NP943_RS08695 (1791293) 1791293..1791952 - 660 WP_000250275.1 hemolysin III family protein -
NP943_RS08700 (1792116) 1792116..1792427 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
NP943_RS08705 (1792472) 1792472..1793905 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T253081 WP_000244765.1 NZ_CP102061:c1789746-1789339 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT253081 WP_000354050.1 NZ_CP102061:c1789993-1789727 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References