Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3725762..3726410 Replicon chromosome
Accession NZ_CP101989
Organism Cellulomonas wangsupingiae strain zg-Y908

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NP075_RS17135 Protein ID WP_227565908.1
Coordinates 3725970..3726410 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NP075_RS17130 Protein ID WP_207339584.1
Coordinates 3725762..3725980 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP075_RS17100 (NP075_17100) 3720829..3721650 - 822 WP_227565886.1 alpha/beta hydrolase -
NP075_RS17105 (NP075_17105) 3721787..3722098 + 312 WP_227565901.1 hypothetical protein -
NP075_RS17110 (NP075_17110) 3722260..3723318 + 1059 WP_227565903.1 5'-3' exonuclease H3TH domain-containing protein -
NP075_RS17115 (NP075_17115) 3723331..3723705 - 375 WP_227565904.1 glyoxalase superfamily protein -
NP075_RS17120 (NP075_17120) 3723898..3724665 + 768 WP_227565905.1 SDR family oxidoreductase -
NP075_RS17125 (NP075_17125) 3724722..3725657 + 936 WP_227565906.1 aldo/keto reductase -
NP075_RS17130 (NP075_17130) 3725762..3725980 + 219 WP_207339584.1 antitoxin Antitoxin
NP075_RS17135 (NP075_17135) 3725970..3726410 + 441 WP_227565908.1 PIN domain-containing protein Toxin
NP075_RS17140 (NP075_17140) 3726449..3727156 - 708 WP_227565910.1 TetR/AcrR family transcriptional regulator -
NP075_RS17145 (NP075_17145) 3727235..3728716 + 1482 WP_227565912.1 MDR family MFS transporter -
NP075_RS17150 (NP075_17150) 3728961..3729947 + 987 WP_227565914.1 polyphosphate polymerase domain-containing protein -
NP075_RS17155 (NP075_17155) 3729944..3730615 + 672 WP_227565916.1 DUF4956 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 15785.21 Da        Isoelectric Point: 8.1789

>T253071 WP_227565908.1 NZ_CP101989:3725970-3726410 [Cellulomonas wangsupingiae]
VTAEPCYLLDVNVLLALAADAHVHHRAAHRWFADVTAWATTPVTESAFVRLLSTPAVLGRTVLPIEAVAALRQMRTVPGH
RFLPDDASFADTTIDLTRMVGPRQVTDFHLVGLARRTGSTLATLDAKLRRSLHPADAHLVSVVPAA

Download         Length: 441 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7666.59 Da        Isoelectric Point: 4.9927

>AT253071 WP_207339584.1 NZ_CP101989:3725762-3725980 [Cellulomonas wangsupingiae]
MRTTLEIDDRVLAAARAIAEQQNVSIGRAISDLAERALEGTAPASTVRGFPVFHGPAGHVITDEMVAEHRDG

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References