Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 4078014..4078657 Replicon chromosome
Accession NZ_CP101987
Organism Cellulomonas xiejunii strain zg-B89

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NP048_RS18785 Protein ID WP_227576839.1
Coordinates 4078014..4078397 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NP048_RS18790 Protein ID WP_227576840.1
Coordinates 4078394..4078657 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP048_RS18755 (NP048_18755) 4073058..4073774 - 717 WP_227576834.1 ABC transporter ATP-binding protein -
NP048_RS18760 (NP048_18760) 4073771..4074544 - 774 WP_256769376.1 ABC transporter ATP-binding protein -
NP048_RS18765 (NP048_18765) 4074647..4075378 - 732 WP_227576836.1 glucose 1-dehydrogenase -
NP048_RS18770 (NP048_18770) 4075450..4076430 - 981 WP_227576837.1 NADPH:quinone oxidoreductase family protein -
NP048_RS18775 (NP048_18775) 4076436..4077077 - 642 WP_227576838.1 TetR/AcrR family transcriptional regulator -
NP048_RS18780 (NP048_18780) 4077088..4077852 - 765 WP_227577210.1 SDR family oxidoreductase -
NP048_RS18785 (NP048_18785) 4078014..4078397 - 384 WP_227576839.1 PIN domain-containing protein Toxin
NP048_RS18790 (NP048_18790) 4078394..4078657 - 264 WP_227576840.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NP048_RS18795 (NP048_18795) 4078939..4079142 + 204 WP_227576841.1 hypothetical protein -
NP048_RS18800 (NP048_18800) 4079372..4080476 + 1105 Protein_3695 crosslink repair DNA glycosylase YcaQ family protein -
NP048_RS18805 (NP048_18805) 4080542..4080688 - 147 WP_227576842.1 helix-turn-helix domain-containing protein -
NP048_RS18810 (NP048_18810) 4080936..4082534 - 1599 WP_227576843.1 TROVE domain-containing protein -
NP048_RS18815 (NP048_18815) 4083260..4083628 + 369 WP_227576844.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-113)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-43)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13223.16 Da        Isoelectric Point: 5.0863

>T253070 WP_227576839.1 NZ_CP101987:c4078397-4078014 [Cellulomonas xiejunii]
VRLVLDTNVLIDGLVPTGTGDEAAISMATLAELRFGVLIARTAESRSARMRVLSSAESALAALPIDDAVASSYALLATKT
VAAGRQPRARAFDLLIAATAHAHGAALVTRNIDDFTGLDDVLDVRLP

Download         Length: 384 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9505.63 Da        Isoelectric Point: 4.4720

>AT253070 WP_227576840.1 NZ_CP101987:c4078657-4078394 [Cellulomonas xiejunii]
MTTVGVRELRQDASGVLRLVEAGERVVVTVHGRPVADLVPHSEARPTWRPVADLAALFRGVDDPDWEQDMALVDGAATDP
FERGSDR

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References