Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 165408..165979 Replicon chromosome
Accession NZ_CP101986
Organism Streptococcus mutans strain COCC33-14

Toxin (Protein)


Gene name mazF Uniprot ID A0A2J9QC66
Locus tag NPS16_RS00835 Protein ID WP_002265705.1
Coordinates 165647..165979 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2J9QC51
Locus tag NPS16_RS00830 Protein ID WP_002264866.1
Coordinates 165408..165653 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPS16_RS00805 (NPS16_00805) 160912..161888 - 977 Protein_137 cell division protein FtsK -
NPS16_RS00810 (NPS16_00810) 161888..162202 - 315 WP_002272250.1 hypothetical protein -
NPS16_RS00815 (NPS16_00815) 162402..163319 + 918 WP_002272249.1 hypothetical protein -
NPS16_RS00820 (NPS16_00820) 163513..163671 + 159 Protein_140 DNA cytosine methyltransferase -
NPS16_RS00825 (NPS16_00825) 163746..164900 + 1155 WP_226718267.1 protein kinase family protein -
NPS16_RS00830 (NPS16_00830) 165408..165653 + 246 WP_002264866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NPS16_RS00835 (NPS16_00835) 165647..165979 + 333 WP_002265705.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NPS16_RS00840 (NPS16_00840) 166177..166968 - 792 WP_002265704.1 nucleotidyltransferase domain-containing protein -
NPS16_RS00845 (NPS16_00845) 167284..169044 + 1761 WP_002265703.1 PDZ domain-containing protein -
NPS16_RS00850 (NPS16_00850) 169046..169663 + 618 WP_002265702.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

Antitoxin PemI-like

(1-81)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12632.50 Da        Isoelectric Point: 6.4634

>T253067 WP_002265705.1 NZ_CP101986:165647-165979 [Streptococcus mutans]
VVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIAIFAPISNTKRDYPFYVPLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9255.55 Da        Isoelectric Point: 4.3021

>AT253067 WP_002264866.1 NZ_CP101986:165408-165653 [Streptococcus mutans]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QC66

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9QC51

References