253066

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) SmuAT/-
Location 155701..156662 Replicon chromosome
Accession NZ_CP101986
Organism Streptococcus mutans strain COCC33-14

Toxin (Protein)


Gene name smuT Uniprot ID A0A2J9QC39
Locus tag NPS16_RS00760 Protein ID WP_002267097.1
Coordinates 155701..156216 (+) Length 172 a.a.

Antitoxin (Protein)


Gene name smuA Uniprot ID A0A829BWH5
Locus tag NPS16_RS00765 Protein ID WP_002269854.1
Coordinates 156216..156662 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPS16_RS00735 (NPS16_00735) 151147..151854 + 708 WP_019322017.1 MerR family transcriptional regulator -
NPS16_RS00740 (NPS16_00740) 151890..152882 - 993 WP_002272255.1 BtrH N-terminal domain-containing protein -
NPS16_RS00745 (NPS16_00745) 153071..153625 - 555 WP_002269064.1 PadR family transcriptional regulator -
NPS16_RS00750 (NPS16_00750) 153939..154685 + 747 WP_002264862.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
NPS16_RS00755 (NPS16_00755) 154709..155569 + 861 WP_002265709.1 DegV family protein -
NPS16_RS00760 (NPS16_00760) 155701..156216 + 516 WP_002267097.1 hypothetical protein Toxin
NPS16_RS00765 (NPS16_00765) 156216..156662 + 447 WP_002269854.1 hypothetical protein Antitoxin
NPS16_RS00770 (NPS16_00770) 156659..156853 + 195 WP_002262994.1 helix-turn-helix transcriptional regulator -
NPS16_RS00775 (NPS16_00775) 157246..157692 + 447 WP_002262993.1 50S ribosomal protein L13 -
NPS16_RS00780 (NPS16_00780) 157717..158109 + 393 WP_002262992.1 30S ribosomal protein S9 -
NPS16_RS00785 (NPS16_00785) 158166..159213 - 1048 Protein_133 site-specific integrase -
NPS16_RS00790 (NPS16_00790) 159303..159482 - 180 WP_002272253.1 helix-turn-helix domain-containing protein -
NPS16_RS00795 (NPS16_00795) 159533..160162 - 630 WP_168742407.1 replication protein -
NPS16_RS00800 (NPS16_00800) 160294..160908 - 615 WP_002272251.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 172 a.a.        Molecular weight: 19512.16 Da        Isoelectric Point: 9.8653

>T253066 WP_002267097.1 NZ_CP101986:155701-156216 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Download         Length: 516 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16998.26 Da        Isoelectric Point: 9.5767

>AT253066 WP_002269854.1 NZ_CP101986:156216-156662 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QC39

Antitoxin

Source ID Structure
AlphaFold DB A0A829BWH5

References