Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1371278..1371864 Replicon chromosome
Accession NZ_CP101985
Organism Streptococcus mutans strain COCC33-14R

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NPS17_RS06320 Protein ID WP_002290797.1
Coordinates 1371673..1371864 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NPS17_RS06315 Protein ID WP_032526274.1
Coordinates 1371278..1371655 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPS17_RS06305 (NPS17_06305) 1368122..1368406 - 285 WP_258968833.1 helix-turn-helix transcriptional regulator -
NPS17_RS06310 (NPS17_06310) 1368722..1369615 + 894 WP_002272311.1 LexA family transcriptional regulator IrvR -
NPS17_RS06315 (NPS17_06315) 1371278..1371655 - 378 WP_032526274.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NPS17_RS06320 (NPS17_06320) 1371673..1371864 - 192 WP_002290797.1 type II toxin-antitoxin system HicA family toxin Toxin
NPS17_RS06325 (NPS17_06325) 1371961..1372623 - 663 WP_258968834.1 type II-A CRISPR-associated protein Csn2 -
NPS17_RS06330 (NPS17_06330) 1372613..1372957 - 345 WP_002263547.1 CRISPR-associated endonuclease Cas2 -
NPS17_RS06335 (NPS17_06335) 1372954..1373820 - 867 WP_014677910.1 type II CRISPR-associated endonuclease Cas1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-107)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7227.53 Da        Isoelectric Point: 10.2062

>T253064 WP_002290797.1 NZ_CP101985:c1371864-1371673 [Streptococcus mutans]
MPLTGKELARLAINNGWEEVRVRESHHDFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Download         Length: 192 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14321.29 Da        Isoelectric Point: 4.5628

>AT253064 WP_032526274.1 NZ_CP101985:c1371655-1371278 [Streptococcus mutans]
MLKSYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALERKLQL

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References