Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | SmuAT/- |
Location | 155701..156662 | Replicon | chromosome |
Accession | NZ_CP101985 | ||
Organism | Streptococcus mutans strain COCC33-14R |
Toxin (Protein)
Gene name | smuT | Uniprot ID | A0A2J9QC39 |
Locus tag | NPS17_RS00760 | Protein ID | WP_002267097.1 |
Coordinates | 155701..156216 (+) | Length | 172 a.a. |
Antitoxin (Protein)
Gene name | smuA | Uniprot ID | A0A829BWH5 |
Locus tag | NPS17_RS00765 | Protein ID | WP_002269854.1 |
Coordinates | 156216..156662 (+) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NPS17_RS00735 (NPS17_00735) | 151147..151854 | + | 708 | WP_019322017.1 | MerR family transcriptional regulator | - |
NPS17_RS00740 (NPS17_00740) | 151890..152882 | - | 993 | WP_002272255.1 | BtrH N-terminal domain-containing protein | - |
NPS17_RS00745 (NPS17_00745) | 153071..153625 | - | 555 | WP_002269064.1 | PadR family transcriptional regulator | - |
NPS17_RS00750 (NPS17_00750) | 153939..154685 | + | 747 | WP_002264862.1 | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | - |
NPS17_RS00755 (NPS17_00755) | 154709..155569 | + | 861 | WP_002265709.1 | DegV family protein | - |
NPS17_RS00760 (NPS17_00760) | 155701..156216 | + | 516 | WP_002267097.1 | hypothetical protein | Toxin |
NPS17_RS00765 (NPS17_00765) | 156216..156662 | + | 447 | WP_002269854.1 | hypothetical protein | Antitoxin |
NPS17_RS00770 (NPS17_00770) | 156659..156853 | + | 195 | WP_002262994.1 | helix-turn-helix transcriptional regulator | - |
NPS17_RS00775 (NPS17_00775) | 157246..157692 | + | 447 | WP_002262993.1 | 50S ribosomal protein L13 | - |
NPS17_RS00780 (NPS17_00780) | 157717..158109 | + | 393 | WP_002262992.1 | 30S ribosomal protein S9 | - |
NPS17_RS00785 (NPS17_00785) | 158166..159213 | - | 1048 | Protein_133 | site-specific integrase | - |
NPS17_RS00790 (NPS17_00790) | 159303..159482 | - | 180 | WP_002272253.1 | helix-turn-helix domain-containing protein | - |
NPS17_RS00795 (NPS17_00795) | 159533..160162 | - | 630 | WP_168742407.1 | replication protein | - |
NPS17_RS00800 (NPS17_00800) | 160294..160908 | - | 615 | WP_002272251.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 172 a.a. Molecular weight: 19512.16 Da Isoelectric Point: 9.8653
>T253062 WP_002267097.1 NZ_CP101985:155701-156216 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
Download Length: 516 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16998.26 Da Isoelectric Point: 9.5767
>AT253062 WP_002269854.1 NZ_CP101985:156216-156662 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J9QC39 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829BWH5 |