Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1329644..1330230 Replicon chromosome
Accession NZ_CP101984
Organism Streptococcus mutans strain UA-159

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NPS18_RS06500 Protein ID WP_002263545.1
Coordinates 1330039..1330230 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q8DTE7
Locus tag NPS18_RS06495 Protein ID WP_002263544.1
Coordinates 1329644..1330021 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPS18_RS06470 (NPS18_06470) 1325045..1325173 - 129 WP_002262718.1 hypothetical protein -
NPS18_RS06475 (NPS18_06475) 1325208..1325438 - 231 WP_002282891.1 hypothetical protein -
NPS18_RS06480 (NPS18_06480) 1325568..1327319 - 1752 WP_002262719.1 GbpC/Spa domain-containing protein -
NPS18_RS06485 (NPS18_06485) 1327482..1327767 - 286 Protein_1247 helix-turn-helix transcriptional regulator -
NPS18_RS06490 (NPS18_06490) 1328082..1328975 + 894 WP_002262721.1 LexA family transcriptional regulator IrvR -
NPS18_RS06495 (NPS18_06495) 1329644..1330021 - 378 WP_002263544.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NPS18_RS06500 (NPS18_06500) 1330039..1330230 - 192 WP_002263545.1 type II toxin-antitoxin system HicA family toxin Toxin
NPS18_RS06505 (NPS18_06505) 1330327..1330989 - 663 WP_002263546.1 type II-A CRISPR-associated protein Csn2 -
NPS18_RS06510 (NPS18_06510) 1330979..1331323 - 345 WP_002263547.1 CRISPR-associated endonuclease Cas2 -
NPS18_RS06515 (NPS18_06515) 1331320..1332186 - 867 WP_002352326.1 type II CRISPR-associated endonuclease Cas1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-106)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7139.47 Da        Isoelectric Point: 10.6223

>T253061 WP_002263545.1 NZ_CP101984:c1330230-1330039 [Streptococcus mutans]
MPLTGKELAKLAINNGWEEVRVRGSHHHFKKDGVSYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Download         Length: 192 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14264.31 Da        Isoelectric Point: 4.5540

>AT253061 WP_002263544.1 NZ_CP101984:c1330021-1329644 [Streptococcus mutans]
MLKSYPVIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGLVLPISSDIQKISVEDGFATMIQADP
SPYLKNNKAIRKNVTVPEWLIRLADRDRVNYSEVLTKALEKKLQL

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q8DTE7

References