Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 849759..850296 Replicon chromosome
Accession NZ_CP101984
Organism Streptococcus mutans strain UA-159

Toxin (Protein)


Gene name relE Uniprot ID Q8DUM3
Locus tag NPS18_RS04230 Protein ID WP_002262889.1
Coordinates 850018..850296 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q8DUM4
Locus tag NPS18_RS04225 Protein ID WP_002262888.1
Coordinates 849759..850031 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPS18_RS04210 (NPS18_04210) 845101..846705 + 1605 WP_002262884.1 type I restriction-modification system subunit M -
NPS18_RS04215 (NPS18_04215) 846698..848509 + 1812 WP_002352261.1 restriction endonuclease subunit S -
NPS18_RS04220 (NPS18_04220) 848540..849685 + 1146 WP_002262887.1 AAA family ATPase -
NPS18_RS04225 (NPS18_04225) 849759..850031 + 273 WP_002262888.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NPS18_RS04230 (NPS18_04230) 850018..850296 + 279 WP_002262889.1 type II toxin-antitoxin system YafQ family toxin Toxin
NPS18_RS04235 (NPS18_04235) 850299..853346 + 3048 WP_002262890.1 type I restriction endonuclease subunit R -
NPS18_RS04240 (NPS18_04240) 853560..853934 + 375 WP_002262891.1 DUF1149 family protein -
NPS18_RS04245 (NPS18_04245) 853940..854785 + 846 WP_002262892.1 DegV family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-76)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10722.79 Da        Isoelectric Point: 10.2475

>T253060 WP_002262889.1 NZ_CP101984:850018-850296 [Streptococcus mutans]
MLKIKQTRQFKKSLKKVVKQGKDINKLFAIVELLCQKSELPLALRNHELKGRWRGIRELHIESDWLLAYQVLDDELVLLL
IDTGSHAQMLGM

Download         Length: 279 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10051.41 Da        Isoelectric Point: 4.4482

>AT253060 WP_002262888.1 NZ_CP101984:849759-850031 [Streptococcus mutans]
MVVKNKANINIKIDLEDKAAADAIFAHMGLTTSAAVNMFIKRVIDDQALPFTPRVKNTLDIALEQAKNDDVETFDSFDDW
KSEMSAYAKD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8DUM3

Antitoxin

Source ID Structure
AlphaFold DB Q8DUM4

References