Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 3121941..3122512 Replicon chromosome
Accession NC_015578
Organism Treponema primitia ZAS-2

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag TREPR_RS13475 Protein ID WP_201765784.1
Coordinates 3121941..3122270 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag TREPR_RS13480 Protein ID WP_041611701.1
Coordinates 3122258..3122512 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TREPR_RS13460 3117746..3119455 + 1710 WP_148257475.1 hypothetical protein -
TREPR_RS13465 3119461..3121299 + 1839 WP_015708875.1 S1C family serine protease -
TREPR_RS13470 3121306..3121785 - 480 WP_015708876.1 pyridoxamine 5'-phosphate oxidase family protein -
TREPR_RS13475 3121941..3122270 - 330 WP_201765784.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
TREPR_RS13480 3122258..3122512 - 255 WP_041611701.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
TREPR_RS13485 3122697..3123356 + 660 WP_174269891.1 outer membrane lipoprotein carrier protein LolA -
TREPR_RS13490 3123428..3124552 + 1125 WP_015708880.1 helix-turn-helix domain-containing protein -
TREPR_RS13495 3124588..3126021 + 1434 WP_174269892.1 30S ribosomal protein S12 methylthiotransferase RimO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin

SpoVT-AbrB domain

(8-48)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12484.86 Da        Isoelectric Point: 10.2440

>T25306 WP_201765784.1 NC_015578:c3122270-3121941 [Treponema primitia ZAS-2]
MGTVMEQYDIFLINLDPTIGHEIKKTRPCLLISPNEMNENIATVIIAPMTTKSHKYPTRVKISLNGTKGWVVLDQIRSID
KKRILKKIGKLNAKNIEEVKNIIREMLVE

Download         Length: 330 bp

>T25306 NC_015578:c3122270-3121941 [Treponema primitia ZAS-2]
TTGGGAACCGTAATGGAACAGTACGATATTTTTTTGATAAATCTTGATCCGACAATAGGGCATGAAATAAAGAAAACACG
GCCATGTCTGCTTATTTCTCCAAATGAAATGAATGAAAATATTGCAACGGTTATTATTGCGCCAATGACAACAAAATCAC
ATAAATATCCAACCCGGGTAAAGATTAGTTTGAATGGAACTAAAGGATGGGTTGTTTTGGATCAAATACGATCAATCGAT
AAAAAAAGGATACTAAAGAAAATTGGAAAGTTAAATGCAAAAAACATAGAAGAAGTAAAGAATATAATAAGAGAAATGCT
GGTAGAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9835.31 Da        Isoelectric Point: 4.5370

>AT25306 WP_041611701.1 NC_015578:c3122512-3122258 [Treponema primitia ZAS-2]
MIVSVVSIGNSRGIRIPKSIINEFNIEDKIELQIHEDELVLKPISKKPRLGWEKAFKKMNENLDDKLIISNTLEDDVFDW
DWEP

Download         Length: 255 bp

>AT25306 NC_015578:c3122512-3122258 [Treponema primitia ZAS-2]
ATGATTGTTTCAGTTGTATCTATTGGCAATTCCAGGGGCATTAGAATTCCCAAAAGTATTATAAATGAATTTAATATTGA
GGATAAAATTGAATTGCAGATACATGAAGATGAATTGGTATTAAAGCCTATATCAAAAAAGCCCCGCTTGGGGTGGGAAA
AGGCGTTTAAAAAAATGAACGAAAATCTTGATGACAAACTCATCATATCAAATACCCTGGAGGATGATGTCTTTGATTGG
GATTGGGAACCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References