Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 110175..111739 Replicon chromosome
Accession NZ_CP101948
Organism Aeromonas salmonicida strain FN1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NP805_RS00520 Protein ID WP_256686509.1
Coordinates 110175..111485 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NP805_RS00525 Protein ID WP_256686511.1
Coordinates 111485..111739 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP805_RS00500 (NP805_00500) 105769..106980 + 1212 WP_256686501.1 O-antigen ligase family protein -
NP805_RS00505 (NP805_00505) 106977..107660 + 684 WP_256686503.1 glycosyltransferase family 25 protein -
NP805_RS00510 (NP805_00510) 107657..108709 + 1053 WP_256686505.1 glycosyltransferase family 9 protein -
NP805_RS00515 (NP805_00515) 108684..109748 - 1065 WP_256686507.1 glycosyltransferase family 9 protein -
NP805_RS00520 (NP805_00520) 110175..111485 - 1311 WP_256686509.1 type II toxin-antitoxin system HipA family toxin Toxin
NP805_RS00525 (NP805_00525) 111485..111739 - 255 WP_256686511.1 helix-turn-helix domain-containing protein Antitoxin
NP805_RS00530 (NP805_00530) 112346..114823 + 2478 WP_256686512.1 DEAD/DEAH box helicase family protein -
NP805_RS00535 (NP805_00535) 114944..116431 + 1488 WP_256686514.1 N-6 DNA methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 105769..120416 14647


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49080.12 Da        Isoelectric Point: 6.7221

>T253056 WP_256686509.1 NZ_CP101948:c111485-110175 [Aeromonas salmonicida]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHGSWLAQPGSRPISLSMPLRHQPYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAVGFEKVQMEMILNEMASSL
DEVISAVSQQLPETFPAQIADSILDGLSTRAQRLTL

Download         Length: 1311 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9367.68 Da        Isoelectric Point: 8.5460

>AT253056 WP_256686511.1 NZ_CP101948:c111739-111485 [Aeromonas salmonicida]
MKVTSAKQLSAYIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References