Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3996264..3996889 Replicon chromosome
Accession NZ_CP101940
Organism Salmonella enterica subsp. enterica strain QA-1986 974

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NP448_RS19710 Protein ID WP_000911337.1
Coordinates 3996491..3996889 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag NP448_RS19705 Protein ID WP_000557545.1
Coordinates 3996264..3996491 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP448_RS19675 (3991327) 3991327..3992425 + 1099 WP_010989230.1 peptide chain release factor 2 -
NP448_RS19680 (3992435) 3992435..3993952 + 1518 WP_000003339.1 lysine--tRNA ligase -
NP448_RS19685 (3994028) 3994028..3994573 - 546 WP_050067887.1 isopentenyl-diphosphate Delta-isomerase -
NP448_RS19690 (3994838) 3994838..3995596 + 759 WP_077947050.1 amidase activator ActS -
NP448_RS19700 (3995842) 3995842..3996055 - 214 Protein_3835 hypothetical protein -
NP448_RS19705 (3996264) 3996264..3996491 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
NP448_RS19710 (3996491) 3996491..3996889 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
NP448_RS19715 (3997690) 3997690..3998226 + 537 WP_058652987.1 STM3031 family outer membrane protein -
NP448_RS19720 (3998273) 3998273..3998905 + 633 WP_000835265.1 YfdX family protein -
NP448_RS19725 (3999624) 3999624..4000208 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3996264..4004680 8416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T253053 WP_000911337.1 NZ_CP101940:3996491-3996889 [Salmonella enterica subsp. enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT253053 WP_000557545.1 NZ_CP101940:3996264-3996491 [Salmonella enterica subsp. enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References