Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2568848..2569629 Replicon chromosome
Accession NZ_CP101940
Organism Salmonella enterica subsp. enterica strain QA-1986 974

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag NP448_RS12720 Protein ID WP_000625911.1
Coordinates 2568848..2569339 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag NP448_RS12725 Protein ID WP_001271379.1
Coordinates 2569336..2569629 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP448_RS12695 (2565728) 2565728..2566558 - 831 WP_023221225.1 fimbria/pilus periplasmic chaperone -
NP448_RS12700 (2566760) 2566760..2566972 - 213 WP_001293880.1 PapB/FocB family fimbrial expression transcriptional regulator -
NP448_RS12705 (2567598) 2567598..2567741 + 144 Protein_2482 transposase -
NP448_RS12710 (2567758) 2567758..2568104 + 347 Protein_2483 Rpn family recombination-promoting nuclease/putative transposase -
NP448_RS12715 (2568385) 2568385..2568633 - 249 Protein_2484 IS481 family transposase -
NP448_RS12720 (2568848) 2568848..2569339 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
NP448_RS12725 (2569336) 2569336..2569629 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
NP448_RS12730 (2569947) 2569947..2570169 + 223 Protein_2487 hypothetical protein -
NP448_RS12735 (2570435) 2570435..2571310 + 876 WP_058653569.1 AraC family transcriptional regulator -
NP448_RS12740 (2571307) 2571307..2571594 + 288 WP_001269916.1 transcriptional regulator RtsB -
NP448_RS12745 (2571587) 2571587..2571769 - 183 WP_071591272.1 ATP-binding cassette domain-containing protein -
NP448_RS12750 (2571789) 2571789..2571888 + 100 Protein_2491 hypothetical protein -
NP448_RS12755 (2571996) 2571996..2572130 + 135 Protein_2492 hypothetical protein -
NP448_RS12760 (2572425) 2572425..2573330 - 906 WP_058653032.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2558240..2571594 13354


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T253047 WP_000625911.1 NZ_CP101940:c2569339-2568848 [Salmonella enterica subsp. enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT253047 WP_001271379.1 NZ_CP101940:c2569629-2569336 [Salmonella enterica subsp. enterica]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References