Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2431216..2431732 Replicon chromosome
Accession NZ_CP101940
Organism Salmonella enterica subsp. enterica strain QA-1986 974

Toxin (Protein)


Gene name relE Uniprot ID A0A7U1KST9
Locus tag NP448_RS12000 Protein ID WP_000220585.1
Coordinates 2431216..2431500 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U1KSR8
Locus tag NP448_RS12005 Protein ID WP_000212721.1
Coordinates 2431490..2431732 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP448_RS11985 (2426332) 2426332..2427984 + 1653 WP_023993572.1 alpha,alpha-phosphotrehalase -
NP448_RS11990 (2428393) 2428393..2430531 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NP448_RS11995 (2430748) 2430748..2431212 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NP448_RS12000 (2431216) 2431216..2431500 - 285 WP_000220585.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP448_RS12005 (2431490) 2431490..2431732 - 243 WP_000212721.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NP448_RS12010 (2431810) 2431810..2433723 - 1914 WP_001212145.1 BglG family transcription antiterminator -
NP448_RS12015 (2433740) 2433740..2434480 - 741 WP_023229489.1 KDGP aldolase family protein -
NP448_RS12020 (2434477) 2434477..2435595 - 1119 WP_023256352.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NP448_RS12025 (2435579) 2435579..2436712 - 1134 WP_023257225.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10878.69 Da        Isoelectric Point: 9.8739

>T253046 WP_000220585.1 NZ_CP101940:c2431500-2431216 [Salmonella enterica subsp. enterica]
MTYELEIDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8995.36 Da        Isoelectric Point: 5.0651

>AT253046 WP_000212721.1 NZ_CP101940:c2431732-2431490 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTFSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U1KST9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U1KSR8

References