Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2389237..2389787 Replicon chromosome
Accession NZ_CP101940
Organism Salmonella enterica subsp. enterica strain QA-1986 974

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag NP448_RS11785 Protein ID WP_001199743.1
Coordinates 2389237..2389545 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag NP448_RS11790 Protein ID WP_001118105.1
Coordinates 2389548..2389787 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP448_RS11770 (2387261) 2387261..2388040 - 780 WP_058653113.1 HNH endonuclease -
NP448_RS11775 (2388201) 2388201..2388515 + 315 WP_058653112.1 hypothetical protein -
NP448_RS11780 (2388512) 2388512..2388801 - 290 Protein_2302 Arm DNA-binding domain-containing protein -
NP448_RS11785 (2389237) 2389237..2389545 - 309 WP_001199743.1 CcdB family protein Toxin
NP448_RS11790 (2389548) 2389548..2389787 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NP448_RS11795 (2389896) 2389896..2390144 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
NP448_RS11800 (2390221) 2390221..2390529 - 309 Protein_2306 DUF4942 domain-containing protein -
NP448_RS11805 (2390549) 2390549..2391526 - 978 WP_223156503.1 IS630 family transposase -
NP448_RS11815 (2392284) 2392284..2393303 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
NP448_RS11820 (2393331) 2393331..2393861 - 531 WP_000896756.1 gluconokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2390549..2391481 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T253045 WP_001199743.1 NZ_CP101940:c2389545-2389237 [Salmonella enterica subsp. enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT253045 WP_001118105.1 NZ_CP101940:c2389787-2389548 [Salmonella enterica subsp. enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References